Zhigang Li,
Associate Professor
Department:
PHHP-COM BIOSTATISTICS
Business Phone:
(352) 294-5915
Business Email:
zhigang.li@ufl.edu
About Zhigang Li
Dr. Zhigang Li is an associate professor with tenure in the Department of Biostatistics at University of Florida. He joined the department as an associate professor in 2018 under the University preeminence initiative. His research interests include microbiome data analysis, mediation analysis, causal inference, high-dimensional data analysis, longitudinal data analysis, survival analysis, joint modeling of longitudinal data and survival in palliative care research. Dr. Li has been PI of multiple NIH grants including his ongoing R01 project “Mediation analysis methods for modeling human microbiome mediating disease-leading causal pathways in children”. Dr. Li loves collaboration with colleagues. He has many years of experience on collaborating with epidemiologists, children’s health experts, environmental health scientists, pediatricians, palliative care researchers, cancer researchers, psychologists, physicians, engineers, neurologists, radiologists, etc.
Related Links:
Accomplishments
Outstanding Student Support Award
2022
·
Department of Biostatistics
Outstanding Teaching Award
2020
·
Department of Biostatistics
University preeminence hire
2018
·
University of Florida
First class prize
1996
·
Chinese National Mathematical Olympiad
Teaching Profile
Courses Taught
2020-2025
PHC7979 Advanced Research
2019-2024
PHC6020 Clinical Trial Methods
2022-2024
PHC6905 Independent Study
2022-2024
PHC7980 Research for Doctoral Dissertation
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-6224-1833
Areas of Interest
- Longitudinal Data Analysis
- Causal inference
- High-dimensional data analysis
- Mediation analysis
- Microbiome
- Survival Analysis
Publications
Academic Articles
2024
ADSS: A Composite Score to Detect Disease Progression in Alzheimer’s Disease.
Journal of Alzheimer's disease reports.
8(1):307-316
[DOI] 10.3233/ADR-230043.
[PMID] 38405343.
2024
Caregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies
Neurology Clinical Practice.
14(3)
[DOI] 10.1212/cpj.0000000000200292.
2024
End-of-life experiences in individuals with dementia with Lewy bodies and their caregivers: A mixed-methods analysis.
PloS one.
19(8)
[DOI] 10.1371/journal.pone.0309530.
[PMID] 39208192.
2024
Experimentally Induced Reductions in Alcohol Consumption and Brain, Cognitive, and Clinical Outcomes in Older Persons With and Those Without HIV Infection (30-Day Challenge Study): Protocol for a Nonrandomized Clinical Trial
JMIR Research Protocols.
13
[DOI] 10.2196/53684.
[PMID] 38564243.
2024
Joint modeling in presence of informative censoring on the retrospective time scale with application to palliative care research.
Biostatistics (Oxford, England).
25(3):754-768
[DOI] 10.1093/biostatistics/kxad028.
[PMID] 37805939.
2024
MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants
Bioinformatics.
2024
Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
20(4):2719-2730
[DOI] 10.1002/alz.13745.
[PMID] 38400528.
2024
Predicting Conversion Time from Mild Cognitive Impairment to Dementia with Interval-Censored Models.
Journal of Alzheimer's disease : JAD.
101(1):147-157
[DOI] 10.3233/JAD-240285.
[PMID] 39121117.
2023
A novel causal mediation analysis approach for zero‐inflated mediators
Statistics in Medicine.
42(13):2061-2081
[DOI] 10.1002/sim.9689.
[PMID] 37071977.
2023
Perceived Effectiveness of Medical Cannabis Among Adults with Chronic Pain: Findings from Interview Data in a Three-Month Pilot Study
Cannabis.
6(2):62-75
[DOI] 10.26828/cannabis/2023/000149.
[PMID] 37484052.
2023
Predicting Progression to Clinical Alzheimer’s Disease Dementia Using the Random Survival Forest.
Journal of Alzheimer's disease : JAD.
95(2):535-548
[DOI] 10.3233/JAD-230208.
[PMID] 37545237.
2022
Batch effects removal for microbiome data via conditional quantile regression
Nature Communications.
13(1)
[DOI] 10.1038/s41467-022-33071-9.
[PMID] 36109499.
2022
MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data.
Genes.
13(6)
[DOI] 10.3390/genes13061049.
[PMID] 35741811.
2022
The relationship between the gut microbiome and the risk of respiratory infections among newborns
Communications Medicine.
2(1)
[DOI] 10.1038/s43856-022-00152-1.
[PMID] 35847562.
2021
IFAA: Robust Association Identification and Inference for Absolute Abundance in Microbiome Analyses.
Journal of the American Statistical Association.
116(536):1595-1608
[DOI] 10.1080/01621459.2020.1860770.
[PMID] 35241863.
2020
Biopsychosocial Influences on Shoulder Pain: Analyzing the Temporal Ordering of Postoperative Recovery.
The journal of pain.
21(7-8):808-819
[DOI] 10.1016/j.jpain.2019.11.008.
[PMID] 31891763.
2018
Conditional Regression Based on a Multivariate Zero-Inflated Logistic-Normal Model for Microbiome Relative Abundance Data.
Statistics in biosciences.
10(3):587-608
[DOI] 10.1007/s12561-018-9219-2.
[PMID] 30923584.
2017
A semiparametric joint model for terminal trend of quality of life and survival in palliative care research
Statistics in Medicine.
36(29):4692-4704
[DOI] 10.1002/sim.7445.
[PMID] 28833347.
2017
Analyzing mHealth Engagement: Joint Models for Intensively Collected User Engagement Data
JMIR mHealth and uHealth.
5(1)
[DOI] 10.2196/mhealth.6474.
[PMID] 28082257.
2017
Effect of Inpatient Palliative Care During Hematopoietic Stem-Cell Transplant on Psychological Distress 6 Months After Transplant: Results of a Randomized Clinical Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
35(32):3714-3721
[DOI] 10.1200/JCO.2017.73.2800.
[PMID] 28926288.
2017
Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
35(8):834-841
[DOI] 10.1200/JCO.2016.70.5046.
[PMID] 28029308.
2015
An Independent Filter for Gene Set Testing Based on Spectral Enrichment.
IEEE/ACM transactions on computational biology and bioinformatics.
12(5):1076-86
[DOI] 10.1109/TCBB.2015.2415815.
[PMID] 26451820.
2015
Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
33(13):1438-45
[DOI] 10.1200/JCO.2014.58.6362.
[PMID] 25800768.
2014
In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort.
Clinical immunology (Orlando, Fla.).
155(2):188-97
[DOI] 10.1016/j.clim.2014.09.004.
[PMID] 25229165.
2014
Optimal design strategies for sibling studies with binary exposures.
The international journal of biostatistics.
10(2):185-96
[DOI] 10.1515/ijb-2014-0015.
[PMID] 25153242.
2013
A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA.
Environmental health perspectives.
121(10):1154-60
[DOI] 10.1289/ehp.1206178.
[PMID] 23872349.
2013
In utero arsenic exposure and infant infection in a United States cohort: a prospective study.
Environmental research.
126:24-30
[DOI] 10.1016/j.envres.2013.05.001.
[PMID] 23769261.
2013
Joint modeling quality of life and survival using a terminal decline model in palliative care studies.
Statistics in medicine.
32(8):1394-406
[DOI] 10.1002/sim.5635.
[PMID] 23001893.
2013
Power and Sample Size Calculations for Generalized Estimating Equations via Local Asymptotics.
Statistica Sinica.
23(1):231-250
[PMID] 24478568.
2013
Syphilis treatment response among HIV-discordant couples in Zambia and Rwanda.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
56(12):1829-37
[DOI] 10.1093/cid/cit146.
[PMID] 23487377.
2009
Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years.
Pediatrics.
124(2):e195-202
[DOI] 10.1542/peds.2008-3506.
[PMID] 19620194.
Presentations
2024-06-16
Joint modeling in presence of informative censoring on the retrospective time scale with application to palliative care research
International
/
Invited.
Symposium.
Nashville, TN
Grants
Sep 2023
ACTIVE
Assessing Benefits and Harms of Medical Cannabis and Cannabinoid Use in Breast Cancer Patients During and After Treatments
Role: Co-Investigator
Funding: UNIV OF MIAMI
via NATL INST OF HLTH NCI
Sep 2023
ACTIVE
Application of deep learning and novel survival models to predict MCI-to-AD dementia progression
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2023
ACTIVE
Photobiomodulation for the management of Temporomandibular disorder pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jan 2023
ACTIVE
Next generation ORS: Randomized controlled trial comparing ORS with calcium vs standard ORS in reducing severity of adults with acute watery diarrhea
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2022
ACTIVE
Technology-based assessments and intervention to reduce alcohol consumption and improve HIV viral suppression in the Florida Cohort
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
Jul 2022
– Jul 2023
Photobiomodulation for the management of Temporomandibular disorder pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
May 2022
ACTIVE
Bacteriophage-mediated microbiota modification to prevent colorectal cancer development
Role: Faculty
Funding: NATL INST OF HLTH NCI
Feb 2022
ACTIVE
Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: A Prospective Cohort Study
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2021
ACTIVE
Southern HIV and Alcohol Research Consortium Biomedical Data Repository
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
Sep 2021
ACTIVE
Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection
Role: Other
Funding: NATL INST OF HLTH NIAAA
Sep 2020
ACTIVE
Identifying Factors Predicting ACcurately End-of-Life in Dementia with Lewy Bodies and Promoting Quality End-of-Life Experiences: the PACE-DLB Study
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2020
ACTIVE
Interdisciplinary Training in Movement Disorders and Neurorestoration
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jul 2020
– Jul 2022
DRPD-ROF2020: Determine the Metabolic Polymorphisms of American Cranberries to Prevent UTIs in Susceptible Women using an Integrated Metabolome-Microbiome Approach
Role: Co-Project Director/Principal Investigator
Funding: UF RESEARCH
Jul 2020
– Jan 2021
Prevalence and Demographics of Multiple Sclerosis in the OneFlorida Data Trust
Role: Principal Investigator
Funding: UNIV OF COLORADO DENVER & ANSCHUTZ MED
via NATL MULTIPLE SCLEROSIS SOC
Feb 2020
– May 2020
Prevalence and Demographics of Multiple Sclerosis in the OneFlorida Data Trust
Role: Co-Investigator
Funding: NATL MULTIPLE SCLEROSIS SOC
Jan 2019
– Dec 2022
Randomized Trial of a Sexual Dysfunction Intervention for HCT Survivors
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL
via AMERICAN CANCER SOCIETY
Aug 2018
– Jul 2023
Mediation Analysis Methods to Model Human Microbiome Mediating Disease-Leading Causal Pathways in Children
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Aug 2017
– Mar 2023
Health outcomes and cognitive effects of marijuana use among persons living with HIV/AIDS
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
Sep 2016
– Aug 2022
Behavioral Science and Biostatistics Resource Cors for Alcohol-HlV Research
Role: Project Manager
Funding: BROWN UNIV
via NATL INST OF HLTH NIAAA
Education
PhD in Biostatistics
2010
·
Columbia University
Master in Statistics
2006
·
Auburn University
MS in Probability Theory
2004
·
Nankai University
BS in Mathematics
2001
·
Nankai University
Contact Details
Phones:
- Business:
- (352) 294-5915
Emails:
- Business:
- zhigang.li@ufl.edu
Addresses:
- Business Mailing:
-
2004 MOWRY RD FL 5
GAINESVILLE FL 32611 - Business Street:
-
2004 MOWRY RD FL 5
GAINESVILLE FL 32610