Zhigang Li

Zhigang Li,

Associate Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5915
Business Email: zhigang.li@ufl.edu

About Zhigang Li

Dr. Zhigang Li is an associate professor with tenure in the Department of Biostatistics at University of Florida. He joined the department as an associate professor in 2018 under the University preeminence initiative. His research interests include microbiome data analysis, mediation analysis, causal inference, high-dimensional data analysis, longitudinal data analysis, survival analysis, joint modeling of longitudinal data and survival in palliative care research. Dr. Li has been PI of multiple NIH grants including his ongoing R01 project “Mediation analysis methods for modeling human microbiome mediating disease-leading causal pathways in children”. Dr. Li loves collaboration with colleagues. He has many years of experience on collaborating with epidemiologists, children’s health experts, environmental health scientists, pediatricians, palliative care researchers, cancer researchers, psychologists, physicians, engineers, neurologists, radiologists, etc.

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Accomplishments

Outstanding Student Support Award
2022 · Department of Biostatistics
Outstanding Teaching Award
2020 · Department of Biostatistics
University preeminence hire
2018 · University of Florida
First class prize
1996 · Chinese National Mathematical Olympiad

Teaching Profile

Courses Taught
2020-2023
PHC7979 Advanced Research
2019-2022
PHC6020 Clinical Trial Methods
2022-2023
PHC6905 Independent Study
2022-2023
PHC7980 Research for Doctoral Dissertation

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-6224-1833

Areas of Interest
  • Longitudinal Data Analysis
  • Causal inference
  • High-dimensional data analysis
  • Mediation analysis
  • Microbiome
  • Survival Analysis

Publications

2022
Batch effects removal for microbiome data via conditional quantile regression
Nature Communications. 13(1) [DOI] 10.1038/s41467-022-33071-9. [PMID] 36109499.
2022
MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data.
Genes. 13(6) [DOI] 10.3390/genes13061049. [PMID] 35741811.
2022
The relationship between the gut microbiome and the risk of respiratory infections among newborns
Communications Medicine. 2(1) [DOI] 10.1038/s43856-022-00152-1. [PMID] 35847562.
2021
IFAA: Robust Association Identification and Inference for Absolute Abundance in Microbiome Analyses.
Journal of the American Statistical Association. 116(536):1595-1608 [DOI] 10.1080/01621459.2020.1860770. [PMID] 35241863.
2020
Biopsychosocial Influences on Shoulder Pain: Analyzing the Temporal Ordering of Postoperative Recovery.
The journal of pain. 21(7-8):808-819 [DOI] 10.1016/j.jpain.2019.11.008. [PMID] 31891763.
2018
Conditional Regression Based on a Multivariate Zero-Inflated Logistic-Normal Model for Microbiome Relative Abundance Data.
Statistics in biosciences. 10(3):587-608 [DOI] 10.1007/s12561-018-9219-2. [PMID] 30923584.
2017
A semiparametric joint model for terminal trend of quality of life and survival in palliative care research
Statistics in Medicine. 36(29):4692-4704 [DOI] 10.1002/sim.7445. [PMID] 28833347.
2017
Analyzing mHealth Engagement: Joint Models for Intensively Collected User Engagement Data
JMIR mHealth and uHealth. 5(1) [DOI] 10.2196/mhealth.6474. [PMID] 28082257.
2017
Effect of Inpatient Palliative Care During Hematopoietic Stem-Cell Transplant on Psychological Distress 6 Months After Transplant: Results of a Randomized Clinical Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(32):3714-3721 [DOI] 10.1200/JCO.2017.73.2800. [PMID] 28926288.
2017
Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(8):834-841 [DOI] 10.1200/JCO.2016.70.5046. [PMID] 28029308.
2015
An Independent Filter for Gene Set Testing Based on Spectral Enrichment.
IEEE/ACM transactions on computational biology and bioinformatics. 12(5):1076-86 [DOI] 10.1109/TCBB.2015.2415815. [PMID] 26451820.
2015
Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(13):1438-45 [DOI] 10.1200/JCO.2014.58.6362. [PMID] 25800768.
2014
In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort.
Clinical immunology (Orlando, Fla.). 155(2):188-97 [DOI] 10.1016/j.clim.2014.09.004. [PMID] 25229165.
2014
Optimal design strategies for sibling studies with binary exposures.
The international journal of biostatistics. 10(2):185-96 [DOI] 10.1515/ijb-2014-0015. [PMID] 25153242.
2013
A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA.
Environmental health perspectives. 121(10):1154-60 [DOI] 10.1289/ehp.1206178. [PMID] 23872349.
2013
In utero arsenic exposure and infant infection in a United States cohort: a prospective study.
Environmental research. 126:24-30 [DOI] 10.1016/j.envres.2013.05.001. [PMID] 23769261.
2013
Joint modeling quality of life and survival using a terminal decline model in palliative care studies.
Statistics in medicine. 32(8):1394-406 [DOI] 10.1002/sim.5635. [PMID] 23001893.
2013
Power and Sample Size Calculations for Generalized Estimating Equations via Local Asymptotics.
Statistica Sinica. 23(1):231-250 [PMID] 24478568.
2013
Syphilis treatment response among HIV-discordant couples in Zambia and Rwanda.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 56(12):1829-37 [DOI] 10.1093/cid/cit146. [PMID] 23487377.
2009
Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years.
Pediatrics. 124(2):e195-202 [DOI] 10.1542/peds.2008-3506. [PMID] 19620194.

Grants

Sep 2022 ACTIVE
Technology-based assessments and intervention to reduce alcohol consumption and improve HIV viral suppression in the Florida Cohort
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
Jul 2022 ACTIVE
Photobiomodulation for the management of Temporomandibular disorder pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
May 2022 ACTIVE
Bacteriophage-mediated microbiota modification to prevent colorectal cancer development
Role: Faculty
Funding: NATL INST OF HLTH NCI
Feb 2022 ACTIVE
Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: A Prospective Cohort Study
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2021 ACTIVE
Southern HIV and Alcohol Research Consortium Biomedical Data Repository
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
Sep 2021 ACTIVE
Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection
Role: Other
Funding: NATL INST OF HLTH NIAAA
Sep 2020 ACTIVE
Identifying Factors Predicting ACcurately End-of-Life in Dementia with Lewy Bodies and Promoting Quality End-of-Life Experiences: the PACE-DLB Study
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2020 ACTIVE
Interdisciplinary Training in Movement Disorders and Neurorestoration
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2020 – Jul 2022
DRPD-ROF2020: Determine the Metabolic Polymorphisms of American Cranberries to Prevent UTIs in Susceptible Women using an Integrated Metabolome-Microbiome Approach
Role: Co-Project Director/Principal Investigator
Funding: UF RESEARCH
Jul 2020 – Jan 2021
Prevalence and Demographics of Multiple Sclerosis in the OneFlorida Data Trust
Role: Principal Investigator
Funding: UNIV OF COLORADO DENVER & ANSCHUTZ MED via NATL MULTIPLE SCLEROSIS SOC
Feb 2020 – May 2020
Prevalence and Demographics of Multiple Sclerosis in the OneFlorida Data Trust
Role: Co-Investigator
Funding: NATL MULTIPLE SCLEROSIS SOC
Jan 2019 ACTIVE
Randomized Trial of a Sexual Dysfunction Intervention for HCT Survivors
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL via AMER CANCER SOC
Aug 2018 ACTIVE
Mediation Analysis Methods to Model Human Microbiome Mediating Disease-Leading Causal Pathways in Children
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Aug 2017 ACTIVE
Health outcomes and cognitive effects of marijuana use among persons living with HIV/AIDS
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
Sep 2016 – Aug 2022
Behavioral Science and Biostatistics Resource Cors for Alcohol-HlV Research
Role: Project Manager
Funding: BROWN UNIV via NATL INST OF HLTH NIAAA

Education

PhD in Biostatistics
2010 · Columbia University
Master in Statistics
2006 · Auburn University
MS in Probability Theory
2004 · Nankai University
BS in Mathematics
2001 · Nankai University

Contact Details

Phones:
Business:
(352) 294-5915
Emails:
Business:
zhigang.li@ufl.edu
Addresses:
Business Mailing:
2004 MOWRY RD FL 5
GAINESVILLE FL 32611
Business Street:
2004 MOWRY RD FL 5
GAINESVILLE FL 32610