Jason O Brant

Jason O Brant,

Research Assistant Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 273-9110
Business Email: jobrant@ufl.edu

About Jason O Brant

The research interests of Dr. Brant are focused on the role of DNA methylation and chromatin structure in regulating gene expression and how perturbations in the epigenome can result in disease onset and progression. Dr. Brant received his doctorate degree from the University of Florida in the department of Biochemistry and Molecular Biology under the mentorship of Dr. Thomas P. Yang. In his current position as a Research Assistant Professor at the UF Health Cancer Center, Dr. Brant works to provide computational and bioinformatics support for cancer center members, and is developing new technologies for assaying chromatin structure.

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Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9800-9251

Publications

2022
Long-term epigenetic and metabolomic changes in the mouse ventricular myocardium after exertional heat stroke
Physiological Genomics. 54(12):486-500 [DOI] 10.1152/physiolgenomics.00147.2021.
2021
Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.717032. [PMID] 34421577.
2021
Exertional heat stroke leads to concurrent long-term epigenetic memory, immunosuppression and altered heat shock response in female mice.
The Journal of physiology. 599(1):119-141 [DOI] 10.1113/JP280518. [PMID] 33037634.
2020
Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus.
The Journal of comparative neurology. 528(9):1535-1547 [DOI] 10.1002/cne.24836. [PMID] 31820438.
2019
Comparative transcriptomic analysis of dermal wound healing reveals de novo skeletal muscle regeneration in Acomys cahirinus
PLOS ONE. 14(5) [DOI] 10.1371/journal.pone.0216228. [PMID] 31141508.
2019
Insights into the regeneration of skin from Acomys , the spiny mouse
Experimental Dermatology. 28(4):436-441 [DOI] 10.1111/exd.13847.
2019
Molecular and histologic outcomes following spinal cord injury in spiny mice,Acomys cahirinus
Jouranl of Comparative Neurology. 528(9):1535-1547 [DOI] 10.1101/793133.
2018
Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus
Scientific Reports. 8(1) [DOI] 10.1038/s41598-018-27178-7. [PMID] 29892004.
2018
Unique behavior of dermal cells from regenerative mammal, the African Spiny Mouse, in response to substrate stiffness.
Journal of biomechanics. 81:149-154 [DOI] 10.1016/j.jbiomech.2018.10.005. [PMID] 30361050.
2016
Cellular events during scar-free skin regeneration in the spiny mouse, Acomys.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(1):75-88 [DOI] 10.1111/wrr.12385. [PMID] 26606280.
2015
A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys.
PloS one. 10(11) [DOI] 10.1371/journal.pone.0142931. [PMID] 26606282.
2015
Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America. 112(22):6871-5 [DOI] 10.1073/pnas.1411261111. [PMID] 25378697.
2015
Correction for Lewis et al., Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America. 112(22) [DOI] 10.1073/pnas.1500034112. [PMID] 25588880.
2014
Influence of the Prader-Willi syndrome imprinting center on the DNA methylation landscape in the mouse brain.
Epigenetics. 9(11):1540-56 [DOI] 10.4161/15592294.2014.969667. [PMID] 25482058.
2011
Are There Changes in Dna Methylation in Response To Chronic Consumption and Withdrawal of Folic Acid in a Population-Based Trial of Reproductive Age Women?
Journal of Developmental Origins of Health and Disease. 2:S126-S127
2010
Improving efficiencies of locus-specific DNA methylation assessment for bovine in vitro produced embryos.
Systems biology in reproductive medicine. 56(1):96-105 [DOI] 10.3109/19396360903331148. [PMID] 20170282.
2009
Assessment of Locus-Specific Dna Methylation: Optimization for Bovine Embryos
Reproduction Fertility and Development. 21(1) [DOI] 10.1071/RDv21n1Ab100.
2009
Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.
Hepatology (Baltimore, Md.). 50(1):282-90 [DOI] 10.1002/hep.22971. [PMID] 19415718.

Grants

Sep 2022 ACTIVE
Mechanisms and blood-based biomarkers of intergenerational neurobehavioral effects of general anesthetics
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD

Education

Doctor of Philosophy
2002-2009 · University of Florida
Bachelor of Science
2000-2002 · State University of New York – Environmental Science and Forestry
Associate of Science
1999-2000 · Hudson Value Community College
Culinary Arts
1992-1994 · Culinary Arts Institute

Contact Details

Phones:
Business:
(352) 273-9110
Emails:
Business:
jobrant@ufl.edu
Addresses:
Business Street:
CGRC 294
2033 Mowry Road
GAINESVILLE FL 32611