Guogen Shan,
Professor
Teaching Profile
Courses Taught
2021
GMS6827 Advanced Clinical Trial Methods
2023
PHC7979 Advanced Research
2023
PHC6937 Special Topics in Public Health
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-8690-6599
Areas of Interest
- Clinical Trials Design & Analysis
- Longitudinal Data Analysis
- Alzheimer’s Disease
- Cognitive Neuroscience
Publications
2023
Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Health Care Providers.
Neurocritical care.
38(2):395-406
[DOI] 10.1007/s12028-022-01571-7.
[PMID] 35915347.
2023
Continuity Corrected Wilson Interval for the Difference of Two Independent Proportions
Journal of Statistical Theory and Applications.
22(1-2):38-53
[DOI] 10.1007/s44199-023-00054-8.
2023
New Confidence Intervals for Relative Risk of Two Correlated Proportions
Statistics in Biosciences.
15(1):1-30
[DOI] 10.1007/s12561-022-09345-7.
[PMID] 35615750.
2023
Promising zone two-stage design for a single-arm study with binary outcome
Statistical Methods in Medical Research.
32(6):1159-1168
[DOI] 10.1177/09622802231164737.
2023
Response adaptive randomization design for a two-stage study with binary response
Journal of Biopharmaceutical Statistics.
33(5):575-585
[DOI] 10.1080/10543406.2023.2170399.
[PMID] 36735855.
2023
Sparring and the Brain: The Associations between Sparring and Regional Brain Volumes in Professional Mixed Martial Arts Fighters
Sports Medicine.
53(8):1641-1649
[DOI] 10.1007/s40279-023-01838-9.
2023
Traumatic encephalopathy syndrome: application of new criteria to a cohort exposed to repetitive head impacts.
British journal of sports medicine.
57(7):389-394
[DOI] 10.1136/bjsports-2022-105819.
[PMID] 36517216.
2023
Two-stage response adaptive randomization designs for multi-arm trials with binary outcome
Journal of Biopharmaceutical Statistics.
1-13
[DOI] 10.1080/10543406.2023.2234028.
2022
Caffeine Enhances Intermittent Hypoxia-Induced Gains in Walking Function for People with Chronic Spinal Cord Injury.
Journal of neurotrauma.
39(23-24):1756-1763
[DOI] 10.1089/neu.2022.0120.
[PMID] 35686460.
2022
Conservative confidence intervals for the intraclass correlation coefficient for clustered binary data
Journal of Applied Statistics.
49(10):2535-2549
[DOI] 10.1080/02664763.2021.1910939.
[PMID] 35757040.
2022
Continuity corrected score confidence interval for the difference in proportions in paired data
Journal of Applied Statistics.
1-14
[DOI] 10.1080/02664763.2022.2118245.
2022
Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol.
Neurological research and practice.
4(1)
[DOI] 10.1186/s42466-022-00168-x.
[PMID] 35067230.
2022
Effects of dose change on the success of clinical trials
Contemporary Clinical Trials Communications.
30
[DOI] 10.1016/j.conctc.2022.100988.
[PMID] 36117568.
2022
Efficacy of Eravacycline Versus Best Previously Available Therapy for Adults With Pneumonia Due to Difficult-to-Treat Resistant (DTR) Acinetobacter baumannii.
The Annals of pharmacotherapy.
56(12):1299-1307
[DOI] 10.1177/10600280221085551.
[PMID] 35511209.
2022
Estimation of bias-corrected intraclass correlation coefficient for unbalanced clustered studies with continuous outcomes
Communications in Statistics – Simulation and Computation.
51(11):6691-6700
[DOI] 10.1080/03610918.2020.1811332.
2022
Evaluating the effects of a mindfulness mobile application on student pharmacists’ stress, burnout, and mindfulness.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
79(8):656-664
[DOI] 10.1093/ajhp/zxab467.
[PMID] 34864830.
2022
Monte Carlo cross-validation for a study with binary outcome and limited sample size.
BMC medical informatics and decision making.
22(1)
[DOI] 10.1186/s12911-022-02016-z.
[PMID] 36253749.
2022
Randomized two-stage optimal design for interval-censored data
Journal of Biopharmaceutical Statistics.
32(2):298-307
[DOI] 10.1080/10543406.2021.2009499.
[PMID] 34890525.
2022
Relationship between advanced pharmacy practice experience grading schemes and pharmacy residency match rates.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
79(24):2261-2270
[DOI] 10.1093/ajhp/zxac254.
[PMID] 36082956.
2021
Advanced statistical methods and designs for clinical trials for COVID-19.
International journal of antimicrobial agents.
57(1)
[DOI] 10.1016/j.ijantimicag.2020.106167.
[PMID] 33408032.
2021
Assessing Clinical Change in Individuals Exposed to Repetitive Head Impacts: The Repetitive Head Impact Composite Index
Frontiers in Neurology.
12
[DOI] 10.3389/fneur.2021.605318.
[PMID] 34295295.
2021
Bootstrap confidence intervals for correlation between continuous repeated measures
Statistical Methods & Applications.
[DOI] 10.1007/s10260-020-00555-1.
2021
Concussion occurrence and recognition in professional boxing and MMA matches: toward a concussion protocol in combat sports
The Physician and Sportsmedicine.
49(4):469-475
[DOI] 10.1080/00913847.2020.1856631.
2021
Economic and workload impact of therapeutic interchange of inhaler medications and nebulizer solutions.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
78(1):41-48
[DOI] 10.1093/ajhp/zxaa343.
[PMID] 33103194.
2021
Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters.
Neurotrauma reports.
2(1):169-179
[DOI] 10.1089/neur.2020.0057.
[PMID] 34223552.
2021
Machine learning methods to predict amyloid positivity using domain scores from cognitive tests
Scientific Reports.
11(1)
[DOI] 10.1038/s41598-021-83911-9.
[PMID] 33649452.
2021
Optimal two-stage designs based on restricted mean survival time for a single-arm study
Contemporary Clinical Trials Communications.
21
[DOI] 10.1016/j.conctc.2021.100732.
[PMID] 33553801.
2021
Partial Correlation Coefficient for a Study With Repeated Measurements
Statistics in Biopharmaceutical Research.
13(4):448-454
[DOI] 10.1080/19466315.2020.1784780.
[PMID] 35003527.
2021
Using the health belief model to assess the impact of student pharmacist-led health outreach events.
Currents in pharmacy teaching & learning.
13(6):694-698
[DOI] 10.1016/j.cptl.2021.01.031.
[PMID] 33867066.
2020
Accurate confidence intervals for proportion in studies with clustered binary outcome
Statistical Methods in Medical Research.
29(10):3006-3018
[DOI] 10.1177/0962280220913971.
2020
Accurate confidence intervals for risk difference in meta-analysis with rare events.
BMC medical research methodology.
20(1)
[DOI] 10.1186/s12874-020-00954-8.
[PMID] 32349702.
2020
Comments on “Exact inference for the random‐effect model for meta‐analyses with rare events”
Statistics in Medicine.
39(22):3022-3023
[DOI] 10.1002/sim.8500.
2020
Correlation Coefficients for a Study with Repeated Measures
Computational and Mathematical Methods in Medicine.
2020:1-11
[DOI] 10.1155/2020/7398324.
[PMID] 32300374.
2020
Evaluation of Guideline Recommendations for Dual Antipseudomonal Therapy in Hospitalized Adults with Pneumonia Using Combination Antibiograms.
Pharmacotherapy.
40(11):1089-1098
[DOI] 10.1002/phar.2466.
[PMID] 33037659.
2020
Exact confidence limits for proportion difference in clinical trials with bilateral outcome
Statistical Methods & Applications.
29(3):515-525
[DOI] 10.1007/s10260-019-00491-9.
2020
Exact Unconditional Tests for Dichotomous Data When Comparing Multiple Treatments With a Single Control
Therapeutic Innovation & Regulatory Science.
54(2):411-417
[DOI] 10.1007/s43441-019-00070-w.
2020
Letter to the Editor: A novel confidence interval for a single proportion in the presence of clustered binary outcome data (SMMR, 2019)
Statistical Methods in Medical Research.
29(2):636-637
[DOI] 10.1177/0962280219840056.
2020
Longitudinal change in regional brain volumes with exposure to repetitive head impacts.
Neurology.
94(3):e232-e240
[DOI] 10.1212/WNL.0000000000008817.
[PMID] 31871218.
2020
Sex Differences in Cognitive Changes in De Novo Parkinson’s Disease.
Journal of the International Neuropsychological Society : JINS.
26(2):241-249
[DOI] 10.1017/S1355617719001085.
[PMID] 31822306.
2020
Sex Moderates the Relationship That Number of Professional Fights Has With Cognition and Brain Volumes.
Frontiers in neurology.
11
[DOI] 10.3389/fneur.2020.574458.
[PMID] 33250844.
2020
The effect of age of first exposure to competitive fighting on cognitive and other neuropsychiatric symptoms and brain volume.
International review of psychiatry (Abingdon, England).
32(1):89-95
[DOI] 10.1080/09540261.2019.1665501.
[PMID] 31587599.
2020
The longitudinal associations between cognition, mood and striatal dopaminergic binding in Parkinson’s Disease.
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition.
27(4):581-594
[DOI] 10.1080/13825585.2019.1653445.
[PMID] 31411534.
2020
The Relationship Between Fighting Style, Cognition, and Regional Brain Volume in Professional Combatants: A Preliminary Examination Using Brief Neurocognitive Measures.
The Journal of head trauma rehabilitation.
35(3):E280-E287
[DOI] 10.1097/HTR.0000000000000540.
[PMID] 31834060.
2020
Two-stage optimal designs based on exact variance for a single-arm trial with survival endpoints
Journal of Biopharmaceutical Statistics.
30(5):797-805
[DOI] 10.1080/10543406.2020.1730869.
[PMID] 32129130.
2019
Associations between Comorbid TDP-43, Lewy Body Pathology, and Neuropsychiatric Symptoms in Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD.
69(4):953-961
[DOI] 10.3233/JAD-181285.
[PMID] 31127776.
2019
Efficient statistical inference for a parallel study with missing data by using an exact method.
Journal of biopharmaceutical statistics.
29(3):478-490
[DOI] 10.1080/10543406.2019.1605782.
[PMID] 31017028.
2019
Estimated Cardiorespiratory Fitness Is Associated With Reported Depression in College Students.
Frontiers in physiology.
10
[DOI] 10.3389/fphys.2019.01191.
[PMID] 31620016.
2019
Exact Unconditional Tests for Dichotomous Data When Comparing Multiple Treatments With a Single Control
Therapeutic Innovation & Regulatory Science.
[DOI] 10.1177/2168479018814697.
2019
Non-motor predictors of freezing of gait in Parkinson’s disease
Gait & Posture.
68:311-316
[DOI] 10.1016/j.gaitpost.2018.12.009.
[PMID] 30553992.
2019
Rejoinder to “Efficient statistical inference for a parallel study with missing data by using an exact method”.
Journal of biopharmaceutical statistics.
29(6):1174-1175
[DOI] 10.1080/10543406.2019.1641819.
[PMID] 31314673.
2019
The Relations Among Depression, Cognition, and Brain Volume in Professional Boxers: A Preliminary Examination Using Brief Clinical Measures.
The Journal of head trauma rehabilitation.
34(6):E29-E39
[DOI] 10.1097/HTR.0000000000000495.
[PMID] 31033751.
2019
Trends and Related Factors of Cannabis-Associated Emergency Department Visits in the United States: 2006-2014.
Journal of addiction medicine.
13(3):193-200
[DOI] 10.1097/ADM.0000000000000479.
[PMID] 30418337.
2019
Two-Stage Bagging Pruning for Reducing the Ensemble Size and Improving the Classification Performance
Mathematical Problems in Engineering.
2019:1-17
[DOI] 10.1155/2019/8906034.
2019
Two-stage optimal designs with survival endpoint when the follow-up time is restricted
BMC Medical Research Methodology.
19(1)
[DOI] 10.1186/s12874-019-0696-x.
[PMID] 30943896.
2018
Accurate unconditional p-values for a two-arm study with binary endpoints.
Journal of statistical computation and simulation.
88(6):1200-1210
[DOI] 10.1080/00949655.2018.1425690.
[PMID] 31080301.
2018
Biomarkers of Cognitive Impairment: Brain Cortical Thickness, Volumetrics, and Cerebrospinal Fluid.
Alzheimer disease and associated disorders.
32(3):255-257
[DOI] 10.1097/WAD.0000000000000226.
[PMID] 29189303.
2018
Biomedical informatics applications for precision management of neurodegenerative diseases.
Alzheimer's & dementia (New York, N. Y.).
4:357-365
[DOI] 10.1016/j.trci.2018.03.007.
[PMID] 30175230.
2018
Determining sample size for a binary diagnostic test in the presence of verification bias.
Journal of biopharmaceutical statistics.
28(6):1193-1202
[DOI] 10.1080/10543406.2018.1452029.
[PMID] 29553878.
2018
Exact confidence limits for the probability of response in two-stage designs.
Statistics.
52(5):1086-1095
[DOI] 10.1080/02331888.2018.1469023.
[PMID] 30906095.
2018
Exact confidence limits for the response rate in two-stage designs with over- or under-enrollment in the second stage.
Statistical methods in medical research.
27(4):1045-1055
[DOI] 10.1177/0962280216650918.
[PMID] 27389669.
2018
Longitudinal Performance of Plasma Neurofilament Light and Tau in Professional Fighters: The Professional Fighters Brain Health Study.
Journal of neurotrauma.
35(20):2351-2356
[DOI] 10.1089/neu.2017.5553.
[PMID] 29609512.
2018
Nevada’s Medicaid expansion and admissions for ambulatory care-sensitive conditions.
The American journal of managed care.
24(5):e157-e163
[PMID] 29851447.
2018
Optimal inference for Simon’s two-stage design with over or under enrollment at the second stage.
Communications in statistics: Simulation and computation.
47(4):1157-1167
[DOI] 10.1080/03610918.2017.1307398.
[PMID] 31097866.
2018
Sample size calculation for agreement between two raters with binary endpoints using exact tests.
Statistical methods in medical research.
27(7):2132-2141
[DOI] 10.1177/0962280216676854.
[PMID] 27856958.
2018
Sample size determination for a matched-pairs study with incomplete data using exact approach.
The British journal of mathematical and statistical psychology.
71(1):60-74
[DOI] 10.1111/bmsp.12107.
[PMID] 28664985.
2018
Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume.
Journal of Alzheimer's disease : JAD.
64(1):79-89
[DOI] 10.3233/JAD-180028.
[PMID] 29865063.
2018
Statistical advances in clinical trials and clinical research.
Alzheimer's & dementia (New York, N. Y.).
4:366-371
[DOI] 10.1016/j.trci.2018.04.006.
[PMID] 30175231.
2017
A better confidence interval for the sensitivity at a fixed level of specificity for diagnostic tests with continuous endpoints.
Statistical methods in medical research.
26(1):268-279
[DOI] 10.1177/0962280214544313.
[PMID] 25049287.
2017
Boundary problem in Simon’s two-stage clinical trial designs.
Journal of biopharmaceutical statistics.
27(1):25-33
[DOI] 10.1080/10543406.2016.1148716.
[PMID] 26881325.
2017
Comments on ‘Two-sample binary phase 2 trials with low type I error and low sample size’
Statistics in Medicine.
36(21):3437-3438
[DOI] 10.1002/sim.7359.
2017
Efficient confidence limits for adaptive one-arm two-stage clinical trials with binary endpoints.
BMC medical research methodology.
17(1)
[DOI] 10.1186/s12874-017-0297-5.
[PMID] 28166741.
2017
Exact one-sided confidence limits for Cohen’s kappa as a measurement of agreement.
Statistical methods in medical research.
26(2):615-632
[DOI] 10.1177/0962280214552881.
[PMID] 25288510.
2017
Exact unconditional sample size determination for paired binary data (letter commenting: J Clin Epidemiol. 2015;68:733-739)
Journal of Clinical Epidemiology.
84:188-190
[DOI] 10.1016/j.jclinepi.2016.07.018.
2017
Fisher’s exact approach for post hoc analysis of a chi-squared test
PLOS ONE.
12(12)
[DOI] 10.1371/journal.pone.0188709.
[PMID] 29261690.
2017
Gaussian network model can be enhanced by combining solvent accessibility in proteins.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-07677-9.
[PMID] 28790346.
2017
Pharmacy Residency School-wide Match Rates and Modifiable Predictors in ACPE-accredited Colleges and Schools of Pharmacy.
American journal of pharmaceutical education.
81(10)
[DOI] 10.5688/ajpe6109.
[PMID] 29367773.
2016
Changes in Inflammatory and Bone Turnover Markers After Periodontal Disease Treatment in Patients With Diabetes.
The American journal of the medical sciences.
351(6):589-94
[DOI] 10.1016/j.amjms.2016.02.004.
[PMID] 27238921.
2016
Exact p-values for Simon’s two-stage designs in clinical trials.
Statistics in biosciences.
8(2):351-357
[DOI] 10.1007/s12561-016-9152-1.
[PMID] 28003856.
2016
Identification of Hot Spots in Protein Structures Using Gaussian Network Model and Gaussian Naive Bayes.
BioMed research international.
2016
[PMID] 27882325.
2016
Minimax and admissible adaptive two-stage designs in phase II clinical trials.
BMC medical research methodology.
16
[DOI] 10.1186/s12874-016-0194-3.
[PMID] 27485595.
2016
Optimal adaptive two-stage designs for early phase II clinical trials.
Statistics in medicine.
35(8):1257-66
[DOI] 10.1002/sim.6794.
[PMID] 26526165.
2016
Racial and Insurance Status Disparities in Patient Safety Indicators among Hospitalized Patients.
Ethnicity & disease.
26(3):443-52
[DOI] 10.18865/ed.26.3.443.
[PMID] 27440986.
2016
Sample size calculation based on efficient unconditional tests for clinical trials with historical controls.
Journal of biopharmaceutical statistics.
26(2):240-9
[DOI] 10.1080/10543406.2014.1000545.
[PMID] 25551261.
2016
Unconditional tests for comparing two ordered multinomials.
Statistical methods in medical research.
25(1):241-54
[DOI] 10.1177/0962280212450957.
[PMID] 22700600.
2015
Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests.
Computational and mathematical methods in medicine.
2015
[DOI] 10.1155/2015/128930.
[PMID] 26366190.
2015
Exact confidence intervals for the relative risk and the odds ratio.
Biometrics.
71(4):985-95
[DOI] 10.1111/biom.12360.
[PMID] 26228945.
2015
Homogeneity test for correlated binary data.
PloS one.
10(4)
[DOI] 10.1371/journal.pone.0124337.
[PMID] 25897962.
2015
Longitudinal trends in asthma health care use in Southern Nevada.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
114(1):70-72.e2
[DOI] 10.1016/j.anai.2014.10.010.
[PMID] 25457866.
2015
Unconditional tests for association in 2 × 2 contingency tables in the total sum fixed design
Statistica Neerlandica.
69(1):67-83
[DOI] 10.1111/stan.12047.
2014
A new powerful nonparametric rank test for ordered alternative problem.
PloS one.
9(11)
[DOI] 10.1371/journal.pone.0112924.
[PMID] 25405757.
2014
Exact approaches for testing hypotheses based on the intra-class kappa coefficient.
Statistics in medicine.
33(17):2998-3012
[DOI] 10.1002/sim.6135.
[PMID] 24634280.
2014
Powerful exact unconditional tests for agreement between two raters with binary endpoints.
PloS one.
9(5)
[DOI] 10.1371/journal.pone.0097386.
[PMID] 24837970.
2014
The effect of a trail use intervention on urban trail use in Southern Nevada
Preventive Medicine.
67:S17-S20
[DOI] 10.1016/j.ypmed.2014.04.027.
2013
A note on exact conditional and unconditional tests for Hardy-Weinberg equilibrium.
Human heredity.
76(1):10-7
[DOI] 10.1159/000353205.
[PMID] 23921792.
2013
Randomized two-stage Phase II clinical trial designs based on Barnard’s exact test.
Journal of biopharmaceutical statistics.
23(5):1081-90
[DOI] 10.1080/10543406.2013.813525.
[PMID] 23957517.
2013
Some tests for detecting trends based on the modified Baumgartner-Weiβ-Schindler statistics.
Computational statistics & data analysis.
57(1):246-261
[PMID] 27030785.
2012
An efficient and exact approach for detecting trends with binary endpoints.
Statistics in medicine.
31(2):155-64
[DOI] 10.1002/sim.4411.
[PMID] 22162106.
2012
Exact two-stage designs for phase II activity trials with rank-based endpoints.
Contemporary clinical trials.
33(2):332-41
[DOI] 10.1016/j.cct.2011.10.008.
[PMID] 22074983.
2012
Two-stage k-sample designs for the ordered alternative problem.
Pharmaceutical statistics.
11(4):287-94
[DOI] 10.1002/pst.1499.
[PMID] 22408050.
Grants
Sep 2023
ACTIVE
Application of deep learning and novel survival models to predict MCI-to-AD dementia progression
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Mar 2023
ACTIVE
Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jan 2023
ACTIVE
Exploring novel therapeutic strategies for combinatory therapy to treat renal clear cell carcinomas
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Sep 2022
ACTIVE
Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic SCI: The BO2ST Trial
Role: Principal Investigator
Funding: SPAULDING REHABILITATION HOSPITAL
via US ARMY MED RES ACQUISITION
Sep 2022
ACTIVE
ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIA
May 2021
ACTIVE
Adaptive randomized designs for cancer clinical trials by using integer algorithms and exact Monte Carlo methods
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
May 2021
ACTIVE
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Education
Ph.D., Biostatistics
2011
·
University at Buffalo
M.A., Biostatistics
2009
·
University at Buffalo
M.S., Bioinformatics
2007
·
Nankai University
B.S., Mathematics
2004
·
Nankai University
Contact Details
Phones:
- Business:
- (352) 294-5934
Emails:
- Business:
- gshan@ufl.edu
Addresses:
- Business Mailing:
-
Box 117450
GAINESVILLE FL 32611