Guogen Shan

Guogen Shan,

Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5934
Business Email: gshan@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-8690-6599

Areas of Interest
  • Clinical Trials Design & Analysis
  • Longitudinal Data Analysis
  • Alzheimer’s Disease
  • Cognitive Neuroscience

Publications

2021
Assessing Clinical Change in Individuals Exposed to Repetitive Head Impacts: The Repetitive Head Impact Composite Index
Frontiers in Neurology. 12 [DOI] 10.3389/fneur.2021.605318. [PMID] 34295295.
2021
Bootstrap confidence intervals for correlation between continuous repeated measures
Statistical Methods & Applications. [DOI] 10.1007/s10260-020-00555-1.
2021
Concussion occurrence and recognition in professional boxing and MMA matches: toward a concussion protocol in combat sports
The Physician and Sportsmedicine. 49(4):469-475 [DOI] 10.1080/00913847.2020.1856631. [PMID] 33251911.
2021
Conservative confidence intervals for the intraclass correlation coefficient for clustered binary data
Journal of Applied Statistics. 1-15 [DOI] 10.1080/02664763.2021.1910939.
2021
Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters.
Neurotrauma reports. 2(1):169-179 [DOI] 10.1089/neur.2020.0057. [PMID] 34223552.
2021
Inpatient palliative care utilisation among patients with gallbladder cancer in the United States: A 10-year perspective.
European journal of cancer care. [DOI] 10.1111/ecc.13520. [PMID] 34633118.
2021
Machine learning methods to predict amyloid positivity using domain scores from cognitive tests
Scientific Reports. 11(1) [DOI] 10.1038/s41598-021-83911-9. [PMID] 33649452.
2021
Optimal two-stage designs based on restricted mean survival time for a single-arm study
Contemporary Clinical Trials Communications. 21 [DOI] 10.1016/j.conctc.2021.100732. [PMID] 33553801.
2021
Partial Correlation Coefficient for a Study With Repeated Measurements
Statistics in Biopharmaceutical Research. 13(4):448-454 [DOI] 10.1080/19466315.2020.1784780.
2021
Using the health belief model to assess the impact of student pharmacist-led health outreach events.
Currents in pharmacy teaching & learning. 13(6):694-698 [DOI] 10.1016/j.cptl.2021.01.031. [PMID] 33867066.
2020
Accurate confidence intervals for proportion in studies with clustered binary outcome
Statistical Methods in Medical Research. 29(10):3006-3018 [DOI] 10.1177/0962280220913971. [PMID] 32242483.
2020
Accurate confidence intervals for risk difference in meta-analysis with rare events.
BMC medical research methodology. 20(1) [DOI] 10.1186/s12874-020-00954-8. [PMID] 32349702.
2020
Comments on “Exact inference for the random‐effect model for meta‐analyses with rare events”
Statistics in Medicine. 39(22):3022-3023 [DOI] 10.1002/sim.8500. [PMID] 32914463.
2020
Correlation Coefficients for a Study with Repeated Measures
Computational and Mathematical Methods in Medicine. 2020:1-11 [DOI] 10.1155/2020/7398324. [PMID] 32300374.
2020
Estimation of bias-corrected intraclass correlation coefficient for unbalanced clustered studies with continuous outcomes
Communications in Statistics – Simulation and Computation. 1-10 [DOI] 10.1080/03610918.2020.1811332.
2020
Evaluation of Guideline Recommendations for Dual Antipseudomonal Therapy in Hospitalized Adults with Pneumonia Using Combination Antibiograms.
Pharmacotherapy. 40(11):1089-1098 [DOI] 10.1002/phar.2466. [PMID] 33037659.
2020
Exact confidence limits for proportion difference in clinical trials with bilateral outcome
Statistical Methods & Applications. 29(3):515-525 [DOI] 10.1007/s10260-019-00491-9.
2020
Exact Unconditional Tests for Dichotomous Data When Comparing Multiple Treatments With a Single Control
Therapeutic Innovation & Regulatory Science. 54(2):411-417 [DOI] 10.1007/s43441-019-00070-w. [PMID] 32072588.
2020
Letter to the Editor: A novel confidence interval for a single proportion in the presence of clustered binary outcome data (SMMR, 2019)
Statistical Methods in Medical Research. 29(2):636-637 [DOI] 10.1177/0962280219840056. [PMID] 30945615.
2020
Longitudinal change in regional brain volumes with exposure to repetitive head impacts.
Neurology. 94(3):e232-e240 [DOI] 10.1212/WNL.0000000000008817. [PMID] 31871218.
2020
Sex Differences in Cognitive Changes in De Novo Parkinson’s Disease.
Journal of the International Neuropsychological Society : JINS. 26(2):241-249 [DOI] 10.1017/S1355617719001085. [PMID] 31822306.
2020
Sex Moderates the Relationship That Number of Professional Fights Has With Cognition and Brain Volumes.
Frontiers in neurology. 11 [DOI] 10.3389/fneur.2020.574458. [PMID] 33250844.
2020
The effect of age of first exposure to competitive fighting on cognitive and other neuropsychiatric symptoms and brain volume.
International review of psychiatry (Abingdon, England). 32(1):89-95 [DOI] 10.1080/09540261.2019.1665501. [PMID] 31587599.
2020
The longitudinal associations between cognition, mood and striatal dopaminergic binding in Parkinson’s Disease.
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 27(4):581-594 [DOI] 10.1080/13825585.2019.1653445. [PMID] 31411534.
2020
The Relationship Between Fighting Style, Cognition, and Regional Brain Volume in Professional Combatants: A Preliminary Examination Using Brief Neurocognitive Measures.
The Journal of head trauma rehabilitation. 35(3):E280-E287 [DOI] 10.1097/HTR.0000000000000540. [PMID] 31834060.
2020
Two-stage optimal designs based on exact variance for a single-arm trial with survival endpoints
Journal of Biopharmaceutical Statistics. 30(5):797-805 [DOI] 10.1080/10543406.2020.1730869. [PMID] 32129130.
2019
Associations between Comorbid TDP-43, Lewy Body Pathology, and Neuropsychiatric Symptoms in Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 69(4):953-961 [DOI] 10.3233/JAD-181285. [PMID] 31127776.
2019
Efficient statistical inference for a parallel study with missing data by using an exact method.
Journal of biopharmaceutical statistics. 29(3):478-490 [DOI] 10.1080/10543406.2019.1605782. [PMID] 31017028.
2019
Estimated Cardiorespiratory Fitness Is Associated With Reported Depression in College Students.
Frontiers in physiology. 10 [DOI] 10.3389/fphys.2019.01191. [PMID] 31620016.
2019
Exact Unconditional Tests for Dichotomous Data When Comparing Multiple Treatments With a Single Control
Therapeutic Innovation & Regulatory Science. [DOI] 10.1177/2168479018814697.
2019
Non-motor predictors of freezing of gait in Parkinson’s disease
Gait & Posture. 68:311-316 [DOI] 10.1016/j.gaitpost.2018.12.009. [PMID] 30553992.
2019
Rejoinder to “Efficient statistical inference for a parallel study with missing data by using an exact method”.
Journal of biopharmaceutical statistics. 29(6):1174-1175 [DOI] 10.1080/10543406.2019.1641819. [PMID] 31314673.
2019
The Relations Among Depression, Cognition, and Brain Volume in Professional Boxers: A Preliminary Examination Using Brief Clinical Measures.
The Journal of head trauma rehabilitation. 34(6):E29-E39 [DOI] 10.1097/HTR.0000000000000495. [PMID] 31033751.
2019
Trends and Related Factors of Cannabis-Associated Emergency Department Visits in the United States: 2006-2014.
Journal of addiction medicine. 13(3):193-200 [DOI] 10.1097/ADM.0000000000000479. [PMID] 30418337.
2019
Two-Stage Bagging Pruning for Reducing the Ensemble Size and Improving the Classification Performance
Mathematical Problems in Engineering. 2019:1-17 [DOI] 10.1155/2019/8906034.
2019
Two-stage optimal designs with survival endpoint when the follow-up time is restricted
BMC Medical Research Methodology. 19(1) [DOI] 10.1186/s12874-019-0696-x. [PMID] 30943896.
2018
Accurate unconditional p-values for a two-arm study with binary endpoints.
Journal of statistical computation and simulation. 88(6):1200-1210 [DOI] 10.1080/00949655.2018.1425690. [PMID] 31080301.
2018
Biomarkers of Cognitive Impairment: Brain Cortical Thickness, Volumetrics, and Cerebrospinal Fluid.
Alzheimer disease and associated disorders. 32(3):255-257 [DOI] 10.1097/WAD.0000000000000226. [PMID] 29189303.
2018
Biomedical informatics applications for precision management of neurodegenerative diseases.
Alzheimer's & dementia (New York, N. Y.). 4:357-365 [DOI] 10.1016/j.trci.2018.03.007. [PMID] 30175230.
2018
Determining sample size for a binary diagnostic test in the presence of verification bias.
Journal of biopharmaceutical statistics. 28(6):1193-1202 [DOI] 10.1080/10543406.2018.1452029. [PMID] 29553878.
2018
Exact confidence limits for the probability of response in two-stage designs.
Statistics. 52(5):1086-1095 [DOI] 10.1080/02331888.2018.1469023. [PMID] 30906095.
2018
Exact confidence limits for the response rate in two-stage designs with over- or under-enrollment in the second stage.
Statistical methods in medical research. 27(4):1045-1055 [DOI] 10.1177/0962280216650918. [PMID] 27389669.
2018
Longitudinal Performance of Plasma Neurofilament Light and Tau in Professional Fighters: The Professional Fighters Brain Health Study.
Journal of neurotrauma. 35(20):2351-2356 [DOI] 10.1089/neu.2017.5553. [PMID] 29609512.
2018
Sample size calculation for agreement between two raters with binary endpoints using exact tests.
Statistical methods in medical research. 27(7):2132-2141 [DOI] 10.1177/0962280216676854. [PMID] 27856958.
2018
Sample size determination for a matched-pairs study with incomplete data using exact approach.
The British journal of mathematical and statistical psychology. 71(1):60-74 [DOI] 10.1111/bmsp.12107. [PMID] 28664985.
2018
Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume.
Journal of Alzheimer's disease : JAD. 64(1):79-89 [DOI] 10.3233/JAD-180028. [PMID] 29865063.
2018
Statistical advances in clinical trials and clinical research.
Alzheimer's & dementia (New York, N. Y.). 4:366-371 [DOI] 10.1016/j.trci.2018.04.006. [PMID] 30175231.
2017
A better confidence interval for the sensitivity at a fixed level of specificity for diagnostic tests with continuous endpoints.
Statistical methods in medical research. 26(1):268-279 [DOI] 10.1177/0962280214544313. [PMID] 25049287.
2017
Boundary problem in Simon’s two-stage clinical trial designs.
Journal of biopharmaceutical statistics. 27(1):25-33 [DOI] 10.1080/10543406.2016.1148716. [PMID] 26881325.
2017
Comments on ‘Two-sample binary phase 2 trials with low type I error and low sample size’
Statistics in Medicine. 36(21):3437-3438 [DOI] 10.1002/sim.7359. [PMID] 28776726.
2017
Efficient confidence limits for adaptive one-arm two-stage clinical trials with binary endpoints.
BMC medical research methodology. 17(1) [DOI] 10.1186/s12874-017-0297-5. [PMID] 28166741.
2017
Exact one-sided confidence limits for Cohen’s kappa as a measurement of agreement.
Statistical methods in medical research. 26(2):615-632 [DOI] 10.1177/0962280214552881. [PMID] 25288510.
2017
Exact unconditional sample size determination for paired binary data (letter commenting: J Clin Epidemiol. 2015;68:733-739)
Journal of Clinical Epidemiology. 84:188-190 [DOI] 10.1016/j.jclinepi.2016.07.018. [PMID] 28063912.
2017
Fisher’s exact approach for post hoc analysis of a chi-squared test
PLOS ONE. 12(12) [DOI] 10.1371/journal.pone.0188709. [PMID] 29261690.
2017
Gaussian network model can be enhanced by combining solvent accessibility in proteins.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-07677-9. [PMID] 28790346.
2017
Pharmacy Residency School-wide Match Rates and Modifiable Predictors in ACPE-accredited Colleges and Schools of Pharmacy.
American journal of pharmaceutical education. 81(10) [DOI] 10.5688/ajpe6109. [PMID] 29367773.
2016
Changes in Inflammatory and Bone Turnover Markers After Periodontal Disease Treatment in Patients With Diabetes.
The American journal of the medical sciences. 351(6):589-94 [DOI] 10.1016/j.amjms.2016.02.004. [PMID] 27238921.
2016
Exact p-values for Simon’s two-stage designs in clinical trials.
Statistics in biosciences. 8(2):351-357 [DOI] 10.1007/s12561-016-9152-1. [PMID] 28003856.
2016
Identification of Hot Spots in Protein Structures Using Gaussian Network Model and Gaussian Naive Bayes.
BioMed research international. 2016 [PMID] 27882325.
View on: PubMed
2016
Minimax and admissible adaptive two-stage designs in phase II clinical trials.
BMC medical research methodology. 16 [DOI] 10.1186/s12874-016-0194-3. [PMID] 27485595.
2016
Optimal adaptive two-stage designs for early phase II clinical trials.
Statistics in medicine. 35(8):1257-66 [DOI] 10.1002/sim.6794. [PMID] 26526165.
2016
Racial and Insurance Status Disparities in Patient Safety Indicators among Hospitalized Patients.
Ethnicity & disease. 26(3):443-52 [DOI] 10.18865/ed.26.3.443. [PMID] 27440986.
2016
Sample size calculation based on efficient unconditional tests for clinical trials with historical controls.
Journal of biopharmaceutical statistics. 26(2):240-9 [DOI] 10.1080/10543406.2014.1000545. [PMID] 25551261.
2016
Unconditional tests for comparing two ordered multinomials.
Statistical methods in medical research. 25(1):241-54 [DOI] 10.1177/0962280212450957. [PMID] 22700600.
2015
Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests.
Computational and mathematical methods in medicine. 2015 [DOI] 10.1155/2015/128930. [PMID] 26366190.
2015
Exact confidence intervals for the relative risk and the odds ratio.
Biometrics. 71(4):985-95 [DOI] 10.1111/biom.12360. [PMID] 26228945.
2015
Longitudinal trends in asthma health care use in Southern Nevada.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 114(1):70-72.e2 [DOI] 10.1016/j.anai.2014.10.010. [PMID] 25457866.
2015
Unconditional tests for association in 2 × 2 contingency tables in the total sum fixed design
Statistica Neerlandica. 69(1):67-83 [DOI] 10.1111/stan.12047.
2014
A new powerful nonparametric rank test for ordered alternative problem.
PloS one. 9(11) [DOI] 10.1371/journal.pone.0112924. [PMID] 25405757.
2014
Exact approaches for testing hypotheses based on the intra-class kappa coefficient.
Statistics in medicine. 33(17):2998-3012 [DOI] 10.1002/sim.6135. [PMID] 24634280.
2014
Powerful exact unconditional tests for agreement between two raters with binary endpoints.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0097386. [PMID] 24837970.
2014
The effect of a trail use intervention on urban trail use in Southern Nevada
Preventive Medicine. 67:S17-S20 [DOI] 10.1016/j.ypmed.2014.04.027. [PMID] 24840942.
2013
A note on exact conditional and unconditional tests for Hardy-Weinberg equilibrium.
Human heredity. 76(1):10-7 [DOI] 10.1159/000353205. [PMID] 23921792.
2013
Randomized two-stage Phase II clinical trial designs based on Barnard’s exact test.
Journal of biopharmaceutical statistics. 23(5):1081-90 [DOI] 10.1080/10543406.2013.813525. [PMID] 23957517.
2013
Some tests for detecting trends based on the modified Baumgartner-Weiβ-Schindler statistics.
Computational statistics & data analysis. 57(1):246-261 [PMID] 27030785.
View on: PubMed
2012
An efficient and exact approach for detecting trends with binary endpoints.
Statistics in medicine. 31(2):155-64 [DOI] 10.1002/sim.4411. [PMID] 22162106.
2012
Exact two-stage designs for phase II activity trials with rank-based endpoints.
Contemporary clinical trials. 33(2):332-41 [DOI] 10.1016/j.cct.2011.10.008. [PMID] 22074983.
2012
Two-stage k-sample designs for the ordered alternative problem.
Pharmaceutical statistics. 11(4):287-94 [DOI] 10.1002/pst.1499. [PMID] 22408050.
Do professional fights go too long?: A video review of concussions and their consequences in professional boxing and MMA matches
. [DOI] 10.1101/2020.04.28.20073221.

Grants

May 2021 ACTIVE
Adaptive randomized designs for cancer clinical trials by using integer algorithms and exact Monte Carlo methods
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
May 2021 ACTIVE
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA

Education

Ph.D., Biostatistics
2011 · University at Buffalo
M.A., Biostatistics
2009 · University at Buffalo
M.S., Bioinformatics
2007 · Nankai University
B.S., Mathematics
2004 · Nankai University

Teaching Profile

Courses Taught
2021
GMS6827 Advanced Clinical Trial Methods

Contact Details

Phones:
Business:
(352) 294-5934
Emails:
Business:
gshan@ufl.edu