Xiangyang Lou

Xiangyang Lou, Ph.D.

Research Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5933
Business Email: xlou@ufl.edu

About Xiangyang Lou

Dr. Lou is a Research Professor in the Department of Biostatistics, the University of Florida and an Adjunct Professor in the Department of Mathematics and Statistics, the University of Arkansas at Little Rock. Dr. Lou earned his Ph.D. in of Statistical Genetics and Bioinformatics from Zhejiang University, China, in 1997. And then he was recruited as an Assistant Professor at Zhejiang University. He came to the U.S. for pursuing postdoctoral training in the Department of Statistics, the University of Florida, in 2002. He was an Assistant Professor at the University of Virginia, an Associate Professor at the University of Alabama at Birmingham, Tulane University, and the University of Arkansas for Medical Sciences, and a Professor at the University of Arkansas for Medical Sciences.

Accomplishments

The 1st prize of Zhejiang Province’s Science and Technology Award in 2006
2006 · Zhejiang Province People’s Government

Teaching Profile

Courses Taught
2021-2022
PHC7979 Advanced Research

Research Profile

Dr. Lou’s research interests include biostatistics, bioinformatics, computational biology, statistical genomics, and study design and data management/innovation for clinical trials. Dr. Lou’s research primarily concentrates on developing and applying powerful innovative analysis methods to solve real-world biological problems in biomedical sciences and other sciences such as detecting multifactor interactions and translating data from disparate and fragmented sources into a holistic biological picture. Specifically, the methodological research includes to develop new machine learning and hidden Markov model-based analytical methods for feature selection and data integration.

Open Researcher and Contributor ID (ORCID)

0000-0002-8305-827X

Areas of Interest
  • Clinical Trials Design & Analysis
  • Big data analytics
  • Bioinformatics
  • Biostatistics
  • Computational biology
  • Statistical methods

Publications

2022
The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma
Neoplasia. 28 [DOI] 10.1016/j.neo.2022.100789. [PMID] 35395492.
2022
Transition to smoking cessation among dual cigarette and e-cigarette users in the population assessment of tobacco and health study, Waves 3 and 4 (2015-2017).
Addictive behaviors. 129 [DOI] 10.1016/j.addbeh.2022.107284. [PMID] 35217415.
2021
Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family‐based hybrid designs
Genetic Epidemiology. 45(2):171-189 [DOI] 10.1002/gepi.22363. [PMID] 32996630.
2020
Brain Cortical Structure and Executive Function in Children May Be Influenced by Parental Choices of Infant Diets
American Journal of Neuroradiology. 41(7):1302-1308 [DOI] 10.3174/ajnr.a6601.
2019
Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes.
Radiology. 292(1):179-187 [DOI] 10.1148/radiol.2019182564. [PMID] 31161971.
2019
Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits
Genetic Epidemiology. 43(1):24-36 [DOI] 10.1002/gepi.22169. [PMID] 30387901.
2018
Dissection of complicate genetic architecture and breeding perspective of cottonseed traits by genome-wide association study.
BMC genomics. 19(1) [DOI] 10.1186/s12864-018-4837-0. [PMID] 29895260.
2017
Genetic dissection of yield traits in super hybrid rice Xieyou9308 using both unconditional and conditional genome-wide association mapping.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-00938-7. [PMID] 28400567.
2016
Dissection of genetic architecture of rice plant height and heading date by multiple-strategy-based association studies.
Scientific reports. 6 [DOI] 10.1038/srep29718. [PMID] 27406081.
2015
Detection of Epistatic and Gene-Environment Interactions Underlying Three Quality Traits in Rice Using High-Throughput Genome-Wide Data.
BioMed research international. 2015 [DOI] 10.1155/2015/135782. [PMID] 26345334.
2015
Dissecting genetic architecture underlying seed traits in multiple environments.
Genetics. 199(1):61-71 [DOI] 10.1534/genetics.114.168203. [PMID] 25335503.
2015
Statistical Analysis of High-Dimensional Genetic Data in Complex Traits
BioMed Research International. 2015:1-2 [DOI] 10.1155/2015/564273. [PMID] 26346557.
2009
Efficient mapping of a female sterile gene in wheat (Triticum aestivum L.).
Genetics research. 91(5):337-43 [DOI] 10.1017/S0016672309990218. [PMID] 19922697.
2008
Analysis of genetic effects of nuclear-cytoplasmic interaction on quantitative traits: genetic models for seed traits of plants.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 116(6):769-76 [DOI] 10.1007/s00122-008-0709-3. [PMID] 18283427.

Grants

Sep 2022 ACTIVE
Functional Decline in Low Functioning Older Adults; Role of iron dysregulation
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2021 ACTIVE
Southern HIV and Alcohol Research Consortium Biomedical Data Repository
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
Aug 2021 ACTIVE
Preclinical Markers of Parkinsonism
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
May 2021 ACTIVE
Immunomodulation Approaches to Improve Safety And Efficacy of Gene Therapy Treatment in Friedreichs Ataxia
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2020 ACTIVE
Phentermine/tOpiramate to end Obesity and Uric acid stones Trial (POuND OUT)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2019 ACTIVE
A telescopic algorithm for two-dimensional hidden Markov models with application to genetic studies
Role: Principal Investigator
Funding: NATL SCIENCE FOU

Education

Post doctorate
2005 · University of Texas Health Science Center at San Antonio
Post doctorate
2004 · University of Florida
Ph.D.
1997 · Zhejiang University, China
Master
1994 · Zhejiang University, China
Associate
1985 · Zhejiang University, China

Contact Details

Phones:
Business:
(352) 294-5933
Emails:
Business:
xlou@ufl.edu
Addresses:
Business Mailing:
PO BOX 117450
GAINESVILLE FL 326110001
Business Street:
2004 MOWRY ROAD, CTRB 5TH FLR.
GAINESVILLE FL 326107450