Ji-Hyun Lee,
Professor & Associate Director For Cancer Quantitative Sciences
Department:
PHHP-COM BIOSTATISTICS
Business Phone:
(352) 273-9079
Business Email:
jihyun.lee@ufl.edu
About Ji-Hyun Lee
Dr. Ji-Hyun Lee is a Professor of Biostatistics in the Department of Biostatistics at the University of Florida and Associate Director for the Cancer Quantitative Sciences at the University of Florida Health Cancer Center (UFHCC). Her role at the UFHCC involves providing strategic leadership and direction, fostering rigorous and integrated research among Cancer Center scientists. Dr. Lee earned her master’s and doctorate in Biostatistics from the University of North Carolina at Chapel Hill. Her research focuses on the design and conduct of clinical trials, cluster/group randomized trials, methods for repeated measurements, and best statistical practices. She also serves on the scientific review and monitoring committee for UFHCC’s therapeutic clinical trials.
Dr. Lee is an elected Fellow of the American Statistical Association (ASA) and a certified professional statistician (PStat®) through the ASA. In 2023, she was elected as the 120th President of the ASA with her term as President-Elect beginning in 2024 and serving President in 2025. Since 2024, Dr. Lee has also served as Chief Statistical Advisor for Oncology at Nature Medicine.
Related Links:
Additional Positions:
Associate Director for Cancer Quantitative Sciences
2024 – Current
·
UF Health Cancer Center
Division Director
2018 – Current
·
Quantitative Sciences, UF Health Cancer Center
Accomplishments
President-Elect
2024
·
American Statistical Association
Elected American Statistical Association Fellow
2018
·
American Statistical Association
Teaching Profile
Courses Taught
2021-2024
PHC6063 Biostatistical Consulting
2022-2025
PHC7979 Advanced Research
2023-2025
PHC7980 Research for Doctoral Dissertation
2024-2025
PHC6905 Independent Study
Teaching Philosophy
Strong theory foundation, Applicability in the real world, Rigor scientific practices, and Ethics.
Research Profile
Dr. Lee’s research focuses on the design and conduct of clinical trials, cluster/group randomized trials, methods for repeated measurements, Bayesian approach, and Best Statistical practices.
Open Researcher and Contributor ID (ORCID)
0000-0001-6420-5150
Areas of Interest
- Clinical Trials Design & Analysis
- Longitudinal Data Analysis
- Cancer AI/ML/Imaging
- Health Disparities
- Smoking Cessation
Publications
Academic Articles
2024
A phase ib clinical trial of oral ciprofloxacin and etoposide in subjects with resistant acute myeloid leukemia.
Leukemia & lymphoma.
65(10):1-9
[DOI] 10.1080/10428194.2024.2361111.
[PMID] 38841781.
2024
A point-of-care pilot randomized intervention to connect patients with cancer-induced financial toxicity to telehealth financial counseling.
Cancer causes & control : CCC.
35(3):393-403
[DOI] 10.1007/s10552-023-01794-9.
[PMID] 37794203.
2024
Absence of Tils in Biopsy is Associated with Worse Progression Free Survival in Early Stage Melanoma
Journal of Clinical & Medical Surgery.
4
2024
Effects on Lung Tissue After Breast Cancer Radiation: Comparing Photon and Proton Therapies.
International journal of particle therapy.
11
[DOI] 10.1016/j.ijpt.2024.02.001.
[PMID] 38757081.
2024
North American Cancer Center Clinical Research Capacity and Benchmarking in the Postpandemic Era.
JCO oncology practice.
[DOI] 10.1200/OP.24.00164.
[PMID] 38950320.
2024
RNA aggregates harness the danger response for potent cancer immunotherapy.
Cell.
187(10):2521-2535.e21
[DOI] 10.1016/j.cell.2024.04.003.
[PMID] 38697107.
2023
A phase II study of neoadjuvant liposomal irinotecan with 5-FU and oxaliplatin (NALIRIFOX) in pancreatic adenocarcinoma.
Future oncology (London, England).
19(27):1841-1851
[DOI] 10.2217/fon-2023-0256.
[PMID] 37753702.
2023
An effectiveness-implementation hybrid trial of phone-based tobacco cessation interventions in the Lebanese primary healthcare system: protocol for project PHOENICS
Implementation Science Communications.
4(1)
[DOI] 10.1186/s43058-023-00456-w.
[PMID] 37365656.
2023
Association of Suppressive Myeloid Cell Enrichment with Aggressive Oropharynx Squamous Cell Carcinoma
Cancers.
15(8)
[DOI] 10.3390/cancers15082346.
[PMID] 37190274.
2023
Colorectal cancer screening completion by patients due or overdue for screening after reminders: a retrospective study
BMC Cancer.
23(1)
[DOI] 10.1186/s12885-023-10837-y.
[PMID] 37127588.
2023
Comparative effectiveness of mobile health smoking cessation approaches among underserved patients in primary care: Study protocol for the PROMOTE-UP trial
Contemporary Clinical Trials.
127
[DOI] 10.1016/j.cct.2023.107120.
2023
Does the Intersectionality of Race/Ethnicity and Type 2 Diabetes Increase the Odds of a Cervical Cancer Diagnosis? A Nested Case-Control Study of a Florida Statewide Multisite EHR Database.
Healthcare (Basel, Switzerland).
11(13)
[DOI] 10.3390/healthcare11131863.
[PMID] 37444697.
2023
Florida-California Cancer Health Equity Center (CaRE2) Community Scientist Research Advocacy Program.
Journal of cancer education : the official journal of the American Association for Cancer Education.
38(5):1429-1439
[DOI] 10.1007/s13187-023-02351-3.
[PMID] 37642919.
2023
Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes.
Cancer control : journal of the Moffitt Cancer Center.
30
[DOI] 10.1177/10732748231197878.
[PMID] 37703814.
2023
Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors
Transplantation and Cellular Therapy.
29(3):202.e1-202.e8
[DOI] 10.1016/j.jtct.2022.11.016.
[PMID] 36427784.
2023
Impact of Institutional Universal Microsatellite-Instability (MSI) Reflex Testing on Molecular Profiling Differences Between Younger and Older Patients with Colorectal Cancer
Clinical Colorectal Cancer.
22(1):153-159
[DOI] 10.1016/j.clcc.2022.09.004.
2023
Mixed methods evaluation of vaping and tobacco product use prevention interventions among youth in the Florida 4-H program
Addictive Behaviors.
141
[DOI] 10.1016/j.addbeh.2023.107637.
2023
Parent Perspectives on Electronic Health Record-Based Social Needs Screening and Documentation: A Qualitative Study
Academic Pediatrics.
[DOI] 10.1016/j.acap.2023.06.011.
2023
Pediatric primary care provider and staff perspectives on the implementation of electronic health record-based social needs interventions: A mixed-methods study
Journal of Clinical and Translational Science.
7(1)
[DOI] 10.1017/cts.2023.585.
2023
Racial and Ethnic Differences in Initiation of Menthol Tobacco Smoking and Subsequent Tobacco Use in the Population Assessment of Tobacco and Health Study, Waves 1–4 (2013–2018)
Nicotine and Tobacco Research.
25(8):1440-1446
[DOI] 10.1093/ntr/ntad055.
2023
Screening for cervical cancer among women with behavioral health conditions-A systematic review
Preventive Medicine Reports.
34
[DOI] 10.1016/j.pmedr.2023.102238.
[PMID] 37273521.
2023
Tumor volume as a predictor of survival in advanced laryngeal cancer treated with total laryngectomy
Head & Neck.
45(6):1376-1388
[DOI] 10.1002/hed.27351.
2022
A novel graphical evaluation of agreement
BMC Medical Research Methodology.
22(1)
[DOI] 10.1186/s12874-022-01532-w.
[PMID] 35184729.
2022
A weight Jackknife approach utilizing linear model based-estimators for clustered data
Communications in Statistics – Simulation and Computation.
53(2):1-20
[DOI] 10.1080/03610918.2022.2039396.
[PMID] 38523866.
2022
Atezolizumab plus tivozanib for immunologically cold tumor types: the IMMCO-1 trial
Future Oncology.
18(34):3815-3822
[DOI] 10.2217/fon-2022-0392.
2022
Clinician Agreement on the Classification of Thyroid Nodules Ultrasound Features: A Survey of 2 Endocrine Societies.
The Journal of clinical endocrinology and metabolism.
107(8):e3288-e3294
[DOI] 10.1210/clinem/dgac279.
[PMID] 35521676.
2022
Developing Capacity in Dissemination and Implementation Research in the Eastern Mediterranean Region: Evaluation of a Training Workshop
Global Implementation Research and Applications.
2(4):340-349
[DOI] 10.1007/s43477-022-00067-y.
[PMID] 36407476.
2022
Does definitive local therapy have a role in select HER2+ de novo metastatic breast cancer patients treated with dual anti-HER2 blockade?
Breast Cancer Research and Treatment.
191(2):375-383
[DOI] 10.1007/s10549-021-06440-z.
2022
Evaluating Regional Nodal Irradiation Allocation and Association with Oncologic Outcomes in NSABP B-18, B-27, B-40, and B-41
International Journal of Radiation Oncology*Biology*Physics.
113(3):542-551
[DOI] 10.1016/j.ijrobp.2022.03.007.
[PMID] 35418342.
2022
Prevalence of cigarette and waterpipe tobacco smoking among adults in three Eastern Mediterranean countries: a cross-sectional household survey
BMJ Open.
12(3)
[DOI] 10.1136/bmjopen-2021-055201.
[PMID] 35246419.
2022
Survival After Minimally Invasive Surgery in Older Women With Endometrial Carcinoma
Anticancer Research.
42(1):75-85
[DOI] 10.21873/anticanres.15459.
2022
Transition to smoking cessation among dual cigarette and e-cigarette users in the population assessment of tobacco and health study, Waves 3 and 4 (2015–2017)
Addictive Behaviors.
129
[DOI] 10.1016/j.addbeh.2022.107284.
2021
Biological features between miRNAs and their targets are unveiled from deep learning models
Scientific Reports.
11(1)
[DOI] 10.1038/s41598-021-03215-w.
[PMID] 34893648.
2021
Chemotherapy education: current practices of oncology nurses counseling patients
Supportive Care in Cancer.
29(12):7323-7328
[DOI] 10.1007/s00520-021-06308-4.
[PMID] 34041616.
2021
Incidence of venous thromboembolism after robotic-assisted hysterectomy in obese patients with endometrial cancer: do we need extended prophylaxis?
Journal of Robotic Surgery.
15(3):343-348
[DOI] 10.1007/s11701-020-01110-6.
2021
miTAR: a hybrid deep learning-based approach for predicting miRNA targets
BMC Bioinformatics.
22(1)
[DOI] 10.1186/s12859-021-04026-6.
[PMID] 33639834.
2021
Primary Care Physician Perspectives on Recommending E-cigarettes to Smokers: a Best-Worst Discrete Choice Experiment
Journal of General Internal Medicine.
36(11):3353-3360
[DOI] 10.1007/s11606-021-06615-w.
[PMID] 33523343.
2020
A Bayesian transition model for missing longitudinal binary outcomes and an application to a smoking cessation study
Statistical Modelling.
20(3):310-338
[DOI] 10.1177/1471082×18821489.
[PMID] 33854408.
2019
A weighted Jackknife method for clustered data
Communications in Statistics – Theory and Methods.
48(8):1963-1980
[DOI] 10.1080/03610926.2018.1440597.
2019
Accurate and efficient estimation of small P-values with the cross-entropy method: applications in genomic data analysis
Bioinformatics.
35(14):2441-2448
[DOI] 10.1093/bioinformatics/bty1005.
[PMID] 30521030.
2019
Tobacco and E-cigarette use among cancer survivors in the United States
PLOS ONE.
14(12)
[DOI] 10.1371/journal.pone.0226110.
[PMID] 31815948.
2019
Two-step approach for assessing the health effects of environmental chemical mixtures: application to simulated datasets and real data from the Navajo Birth Cohort Study
Environmental Health.
18(1)
[DOI] 10.1186/s12940-019-0482-6.
[PMID] 31072361.
2018
Sample size calculations for group randomized trials with unequal group sizes through Monte Carlo simulations
Statistical Methods in Medical Research.
27(9):2569-2580
[DOI] 10.1177/0962280216682775.
2017
A Latent Promotion Time Cure Rate Model using Dependent Tail-Free Mixtures
Journal of the Royal Statistical Society Series A: Statistics in Society.
180(3):891-905
[DOI] 10.1111/rssa.12226.
2017
Outcomes in Women With Cytology Showing Atypical Squamous Cells of Undetermined Significance With vs Without Human Papillomavirus Testing
JAMA Oncology.
3(10):1327-1334
[DOI] 10.1001/jamaoncol.2017.1040.
[PMID] 28655061.
2017
Population-Based Incidence Rates of Cervical Intraepithelial Neoplasia in the Human Papillomavirus Vaccine Era.
JAMA oncology.
3(6):833-837
[DOI] 10.1001/jamaoncol.2016.3609.
[PMID] 27685805.
2017
The Validation of a Beta-Binomial Model for Overdispersed Binomial Data.
Communications in statistics: Simulation and computation.
46(2):807-814
[DOI] 10.1080/03610918.2014.960091.
[PMID] 29276335.
2015
Acceptance and adherence to chemoprevention among women at increased risk of breast cancer
The Breast.
24(1):51-56
[DOI] 10.1016/j.breast.2014.11.006.
[PMID] 25491191.
Presentations
2023-11-02
Best Statistical Practices and Statistical Leadership
International
/
Invited.
Keynote.
South Korea
2024-03-25
It’s All About Data
State
/
Invited.
Speech.
West Port High School, Ocala, FL.
2023-03-22
Everyday Statistician/ Statistical Leadership in Multidisciplinary Work.
Regional
/
Invited.
Keynote.
Lexington, KY
2023-05-03
Everyday Statistician/ Statistical Leadership in Multidisciplinary Work
National
/
Invited.
Keynote.
Atlanta, GA
2024-05-14
Everyday Statistician/ Statistical Leadership in Multidisciplinary Work.
National
/
Invited.
Keynote.
Philadelphia, PA
2024-05-24
Everyday Statistician/ Statistical Leadership in Multidisciplinary Work.
National
/
Invited.
Keynote.
Storrs, Connecticut
2024-07-05
Everyday Statistician/ Statistical Leadership in Multidisciplinary Work.
International
/
Invited.
Keynote.
Seoul, South Korea
2025-07-03
Everyday Statistician/ Statistical Leadership in Multidisciplinary Work.
International
/
Invited.
Keynote.
Ilsan, South Korea
2024-07-11
Statistical Leadership in Team Science
International
/
Invited.
Keynote.
Seoul, South Korea
Grants
Dec 2023
ACTIVE
ADVANCING THALAMIC NEUROSTIMULATION FOR SUPPRESING ESSENTIAL VOICE TREMOR
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2023
ACTIVE
Genetic Attributions and Racialized Perceptions of Obesity
Role: Co-Investigator
Funding: COLUMBIA UNIVERSITY
via NATL INST OF HLTH NHGRI
Sep 2023
ACTIVE
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Other
Funding: NATL INST OF HLTH NCI
Jul 2023
ACTIVE
Exploring microRNA degradation in T-cell acute lymphoblastic leukemia
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2023
ACTIVE
Sustainability of Tobacco Cessation Programs at NCI-Designated Cancer Centers
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jun 2023
ACTIVE
UF Health Cancer Center Support Grant
Role: Other
Funding: NATL INST OF HLTH NCI
Jun 2023
ACTIVE
High Intensity Interval Training: Optimizing Exercise Therapy to Mitigate Cardiovascular Disease Risk Following Breast Cancer Chemotherapy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jan 2023
ACTIVE
Phase I trial of multilamellar mRNA lipid particles for recurrent pediatric high-grade glioma
Role: Project Manager
Funding: ALEXS LEMONADE STAND FOUNDATION
Sep 2022
ACTIVE
Phone Enabled Implementation of Cessation Support (PHOENICS)
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2022
ACTIVE
A phase I study of RNA-lipid particle vaccines for newly-diagnosed glioblastoma, IND19304 05/21/2020
Role: Other
Funding: US FOOD AND DRUG ADMN
Aug 2022
ACTIVE
Leveraging Mammalian Cancers, Platinum-Quality Genome Assemblies, and Large-Scale Data to Identify Mechanisms of Rare Human Cancers
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2022
ACTIVE
Leveraging RNA-lipid nanoparticle vaccines to induce immune response in metastatic pulmonary osteosarcoma
Role: Co-Investigator
Funding: THE V FOU FOR CANCER RESEARCH
May 2022
ACTIVE
Comparative Effectiveness of Mobile Health Smoking Cessation Approaches among Underserved Patients in Primary Care
Role: Co-Investigator
Funding: PATIENT-CENTERED OUTCOMES RES INST
Apr 2022
ACTIVE
Novel RNA-Nanoparticle vaccine for treatment of early melanoma recurrence following adjuvant anti-PD-1 antibody therapy
Role: Co-Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Apr 2022
– Sep 2024
Point-of-care intervention to address financial toxicity in families facing pediatric cancer
Role: Co-Investigator
Funding: FL DEPT OF HLTH LIVE LIKE BELLA
Jan 2022
– Jun 2023
Unveiling Inequities in Palliative and Supportive Care for Metastatic Breast Cancer Patients in the State of Florida
Role: Co-Investigator
Funding: PFIZER INC
Jun 2021
ACTIVE
All-Extremity Exercise as a Novel Strategy for Optimizing Cardiovascular Function during Chemotherapy for Breast Cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Apr 2021
ACTIVE
Enhancing Access to Cancer Clinical Trials among Underrepresented Patients by Building the Capacity of Primary Care Providers: A Study of a Novel Online Training Intervention
Role: Co-Investigator
Funding: LEUKEMIA & LYMPHOMA SOC
Feb 2021
ACTIVE
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Sep 2020
– Aug 2021
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular Carcinoma
Role: Other
Funding: NATL INST OF HLTH NCATS
Jul 2020
– Jul 2021
Remodeling Host Immunity in Oral Cancer with Personalized RNA Nanoparticle Vaccines
Role: Other
Funding: NATL INST OF HLTH NIDCR
Sep 2019
– Aug 2024
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2019
ACTIVE
The role of DNMT3A mutations in clonal heterogeneity and evolution of hematopoiesis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2018
– Aug 2023
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Mar 2016
– Jun 2021
Early markers of subclinical pulmonary vascular radiation toxicity in breast cancer
Role: Project Manager
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Education
DrPH/Biostatistics
2003
·
University of North Carolina at Chapel Hill
MS/Biostatistics
2000
·
University of North Carolina at Chapel Hill
Contact Details
Phones:
- Business:
- (352) 273-9079
Emails:
- Business:
- jihyun.lee@ufl.edu
Administrative Specialist II:
Addresses:
- Business Mailing:
-
PO BOX 103633
GAINESVILLE FL 326100001 - Business Street:
-
2033 MOWRY RD
GAINESVILLE FL 32611