Ji-Hyun Lee

Ji-Hyun Lee,

Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 273-9079
Business Email: jihyun.lee@ufl.edu

About Ji-Hyun Lee

Dr. Ji-Hyun Lee is a Professor of Biostatistics at the Department of Biostatistics in the University of Florida as well as Director of the Division of Quantitative Sciences at the University of Florida Health Cancer Center (UFHCC). Her responsibility at the UFHCC is to provide strategic leadership and administrative direction for the integrated and rigorous research for the Cancer Center scientists. Dr. Lee earned her master’s degree and doctorate in Biostatistics from the University of North Carolina at Chapel Hill. Her research focuses on design and conduct of clinical trials, cluster/group randomized trials, methods for repeated measurements, Bayesian approach, and Best Statistical practices. She has authored over 170 peer-reviewed articles, particularly focused on therapeutic cancer research, social behavior intervention development (including smoking cessation intervention), and population sciences in the health disparity field. As a lead statistician, she has served on or directed several Biostatistical Cores in large programmatic grants including SPORE, P30, and P50. She serves the scientific review and monitoring committee for the UFHCC therapeutic clinical trials.

Dr. Lee is an elected American Statistical Association (ASA) Fellow and a certified professional statistician through the ASA (PStat®).

In 2023, Dr. Lee has been elected as the 120th ASA President and she will serve as the ASA President-Elect and President in 2024-2025.

Related Links:
Additional Positions:
Director
2018 – Present · Division of Quantitative Sciences, UF Health Cancer Center

Accomplishments

Elected American Statistical Association Fellow
2018 · American Statistical Association

Teaching Profile

Courses Taught
2021-2023
PHC6063 Biostatistical Consulting
2022-2023
PHC7979 Advanced Research
2023
PHC7980 Research for Doctoral Dissertation
Teaching Philosophy
Strong theory foundation, Applicability in the real world, Rigor scientific practices, and Ethics.

Research Profile

Dr. Lee’s research focuses on the design and conduct of clinical trials, cluster/group randomized trials, methods for repeated measurements, Bayesian approach, and Best Statistical practices.

Open Researcher and Contributor ID (ORCID)

0000-0001-6420-5150

Areas of Interest
  • Clinical Trials Design & Analysis
  • Longitudinal Data Analysis
  • Cancer AI/ML/Imaging
  • Health Disparities
  • Smoking Cessation

Publications

2023
Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts
eLife. 12 [DOI] 10.7554/elife.81929.
2022
A Two-Part Mixed Model for Differential Expression Analysis in Single-Cell High-Throughput Gene Expression Data
Genes. 13(2) [DOI] 10.3390/genes13020377. [PMID] 35205420.
2022
Author response: Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts
. [DOI] 10.7554/elife.81929.sa2.
2022
Evaluation of phase I clinical trial designs for combinational agents along with guidance based on simulation studies
Journal of Applied Statistics. 1-24 [DOI] 10.1080/02664763.2022.2105827.
2022
Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells
Cancers. 14(5) [DOI] 10.3390/cancers14051126. [PMID] 35267434.
2021
Concordance Between Electronic Health Record and Tumor Registry Documentation of Smoking Status Among Patients With Cancer
JCO Clinical Cancer Informatics. (5):518-526 [DOI] 10.1200/cci.20.00187.
2021
Incidence of venous thromboembolism after robotic-assisted hysterectomy in obese patients with endometrial cancer: do we need extended prophylaxis?
Journal of Robotic Surgery. 15(3):343-348 [DOI] 10.1007/s11701-020-01110-6.
2021
miTAR: a hybrid deep learning-based approach for predicting miRNA targets
BMC Bioinformatics. 22(96) [DOI] https://doi.org/10.1186/s12859-021-04026-6.
2021
Phase II Study of 5-Fluorouracil, Oxaliplatin plus Dasatinib (FOLFOX-D) in First-Line Metastatic Pancreatic Adenocarcinoma
The Oncologist. 26(10):825-e1674 [DOI] 10.1002/onco.13853. [PMID] 34101295.
2019
Tobacco and E-cigarette use among cancer survivors in the United States
PLOS ONE. 14(12) [DOI] 10.1371/journal.pone.0226110. [PMID] 31815948.
2015
Acceptance and adherence to chemoprevention among women at increased risk of breast cancer
The Breast. 24(1):51-56 [DOI] 10.1016/j.breast.2014.11.006. [PMID] 25491191.
2015
The role of principal and secondary diagnoses of hospitalized eye trauma: a nationwide cohort in Taiwan, 1996-2010.
PloS one. 10(4) [DOI] 10.1371/journal.pone.0123348. [PMID] 25884507.
Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: From experimental discovery to validation in two independent patient cohorts
. [DOI] 10.1101/2022.10.25.22281522.

Grants

Jan 2023 ACTIVE
Phase I trial of multilamellar mRNA lipid particles for recurrent pediatric high-grade glioma
Role: Project Manager
Funding: ALEXS LEMONADE STAND FOUNDATION
Sep 2022 ACTIVE
Phone Enabled Implementation of Cessation Support (PHOENICS)
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2022 ACTIVE
Leveraging Mammalian Cancers, Platinum-Quality Genome Assemblies, and Large-Scale Data to Identify Mechanisms of Rare Human Cancers
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2022 ACTIVE
Leveraging RNA-lipid nanoparticle vaccines to induce immune response in metastatic pulmonary osteosarcoma
Role: Co-Investigator
Funding: THE V FOU FOR CANCER RESEARCH
May 2022 ACTIVE
Comparative Effectiveness of Mobile Health Smoking Cessation Approaches among Underserved Patients in Primary Care
Role: Co-Investigator
Funding: PATIENT-CENTERED OUTCOMES RES INST
Apr 2022 ACTIVE
Point-of-care intervention to address financial toxicity in families facing pediatric cancer
Role: Co-Investigator
Funding: FL DEPT OF HLTH LIVE LIKE BELLA
Jan 2022 ACTIVE
Unveiling Inequities in Palliative and Supportive Care for Metastatic Breast Cancer Patients in the State of Florida
Role: Co-Investigator
Funding: PFIZER INC
Jun 2021 ACTIVE
All-Extremity Exercise as a Novel Strategy for Optimizing Cardiovascular Function during Chemotherapy for Breast Cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Apr 2021 ACTIVE
Enhancing Communication Skills of Primary Care Providers to Improve Patient Access to Clinical Trials and Quality Cancer Care.
Role: Co-Investigator
Funding: LEUKEMIA & LYMPHOMA SOC
Feb 2021 ACTIVE
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Sep 2020 – Aug 2021
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular Carcinoma
Role: Other
Funding: NATL INST OF HLTH NCATS
Jul 2020 – Jul 2021
Remodeling Host Immunity in Oral Cancer with Personalized RNA Nanoparticle Vaccines
Role: Other
Funding: NATL INST OF HLTH NIDCR
Sep 2019 ACTIVE
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2019 ACTIVE
The role of DNMT3A mutations in clonal heterogeneity and evolution of hematopoiesis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2018 ACTIVE
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Project Manager
Funding: NATL INST OF HLTH NCI
Mar 2016 – Jun 2021
Early markers of subclinical pulmonary vascular radiation toxicity in breast cancer
Role: Project Manager
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE

Education

DrPH/Biostatistics
2003 · University of North Carolina at Chapel Hill
MS/Biostatistics
2000 · University of North Carolina at Chapel Hill

Contact Details

Phones:
Business:
(352) 273-9079
Emails:
Business:
jihyun.lee@ufl.edu
Administrative Specialist I:
Addresses:
Business Mailing:
PO BOX 103633
GAINESVILLE FL 326100001
Business Street:
2033 MOWRY RD STE 145
GAINESVILLE FL 32610