John A Kairalla

John A Kairalla,

Associate Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5918
Business Email: johnkair@ufl.edu

About John A Kairalla

John Kairalla is a Research Associate Professor and Associate Program Director of the Children’s Oncology Group, Statistics and Data Center-Gainesville in the Department of Biostatistics at the University of Florida. He received his PhD in Biostatistics from the University of North Carolina at Chapel Hill. His current research focus is in clinical trial design, development, monitoring, and analysis with applications in childhood cancer research with a focus on late phase pediatric Acute Lymphoblastic Leukemia (ALL) trials.

Publications

2021
Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children’s Oncology Group.
Pediatric blood & cancer. 68(4) [DOI] 10.1002/pbc.28913. [PMID] 33522102.
2021
Bayesian adaptive trial design for a continuous biomarker with possibly nonlinear or nonmonotone prognostic or predictive effects.
Biometrics. [DOI] 10.1111/biom.13550. [PMID] 34415052.
2021
Correction to: FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children’s Oncology Group trial AALL0631.
Leukemia. 35(5) [DOI] 10.1038/s41375-021-01245-x. [PMID] 33846544.
2021
Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children’s Oncology Group AALL0932.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 39(13):1437-1447 [DOI] 10.1200/JCO.20.00494. [PMID] 33411585.
2021
FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children’s Oncology Group trial AALL0631.
Leukemia. 35(5):1279-1290 [DOI] 10.1038/s41375-021-01177-6. [PMID] 33623141.
2020
Impact of Intrathecal Triple Therapy Versus Intrathecal Methotrexate on Disease-Free Survival for High-Risk B-Lymphoblastic Leukemia: Children’s Oncology Group Study AALL1131.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 38(23):2628-2638 [DOI] 10.1200/JCO.19.02892. [PMID] 32496902.
2020
Point and interval estimation in two-stage adaptive designs with time to event data and biomarker-driven subpopulation selection.
Statistics in medicine. 39(19):2568-2586 [DOI] 10.1002/sim.8557. [PMID] 32363603.
2019
Derivation and measurement consistency of a novel biofluid dynamics measure of deglutitive bolus-driving function-pharyngeal swallowing power.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 31(1) [DOI] 10.1111/nmo.13465. [PMID] 30246422.
2019
Mitochondrial DNA variants and pulmonary function in older persons.
Experimental gerontology. 115:96-103 [DOI] 10.1016/j.exger.2018.11.023. [PMID] 30508565.
2019
Trial Design Challenges and Approaches for Precision Oncology in Rare Tumors: Experiences of the Children’s Oncology Group.
JCO precision oncology. 3 [DOI] 10.1200/PO.19.00060. [PMID] 32923863.
2018
Association of Admission Functional Status and Assistive Device Provision for Veterans Poststroke: A Retrospective Study.
American journal of physical medicine & rehabilitation. 97(12):897-903 [DOI] 10.1097/PHM.0000000000000997. [PMID] 29985819.
2018
Bolus volume and viscosity effects on pharyngeal swallowing power-How physiological bolus accommodation affects bolus dynamics.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 30(12) [DOI] 10.1111/nmo.13481. [PMID] 30324641.
2018
Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children’s Oncology Group Trial AALL0622.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 36(22):2306-2314 [DOI] 10.1200/JCO.2017.76.7228. [PMID] 29812996.
2018
Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed.
GeroScience. 40(5-6):497-511 [DOI] 10.1007/s11357-018-0043-x. [PMID] 30338417.
2018
Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults.
Journal of the American Heart Association. 7(18) [DOI] 10.1161/JAHA.118.010009. [PMID] 30371200.
2018
Relationship between the number of behavioral symptoms in dementia and caregiver distress: what is the tipping point?
International psychogeriatrics. 30(8):1099-1107 [DOI] 10.1017/S104161021700237X. [PMID] 29143722.
2017
Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children’s Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(23):2700-2707 [DOI] 10.1200/JCO.2016.71.7587. [PMID] 28671857.
2017
Reply to I.J. Cohen.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(35):3989-3991 [DOI] 10.1200/JCO.2017.75.7252. [PMID] 29045162.
2016
A Pilot Study of Intensified PEG-Asparaginase in High-risk Acute Lymphoblastic Leukemia: Children’s Oncology Group Study AALL08P1.
Journal of pediatric hematology/oncology. 38(6):409-17 [DOI] 10.1097/MPH.0000000000000589. [PMID] 27299599.
2016
Anticholinergic Drug Use and Risk to Cognitive Performance in Older Adults with Questionable Cognitive Impairment: A Cross-Sectional Analysis.
Drugs & aging. 33(11):809-818 [PMID] 27638818.
View on: PubMed
2016
Understanding the Provision of Assistive Mobility and Daily Living Devices and Service Delivery to Veterans After Stroke.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association. 70(1):7001290020p1-7001290020p10 [DOI] 10.5014/ajot.2016.015768. [PMID] 26709432.
2015
Adaptive designs for comparative effectiveness research trials.
Clinical research and regulatory affairs. 32(1):36-44 [PMID] 27773984.
View on: PubMed
2014
Rituximab in idiopathic nephrotic syndrome: does it make sense?
Pediatric nephrology (Berlin, Germany). 29(8):1313-9 [DOI] 10.1007/s00467-013-2534-4. [PMID] 23793923.
2013
A randomized controlled trial to improve health among women receiving welfare in the US: the relationship between employment outcomes and the economic recession.
Social science & medicine (1982). 80:130-40 [DOI] 10.1016/j.socscimed.2012.08.011. [PMID] 22963921.
2013
Epithelial-mesenchymal transition and cancer stem cells in endometrial cancer.
Anticancer research. 33(12):5461-9 [PMID] 24324082.
View on: PubMed
2012
Adaptive trial designs: a review of barriers and opportunities.
Trials. 13 [DOI] 10.1186/1745-6215-13-145. [PMID] 22917111.
2012
Arterial Pulsations Are Unrelated To the Throbbing Quality of Acute Pain
. 78
2012
Association between perinatal medical expenses and a waiver to increase Florida healthy start services within Florida medicaid programs: 1998 to 2006.
Maternal and child health journal. 16(8):1567-75 [DOI] 10.1007/s10995-011-0811-z. [PMID] 21559775.
2012
Does hydronephrosis predict the presence of severe vesicoureteral reflux?
European journal of pediatrics. 171(11):1605-10 [DOI] 10.1007/s00431-012-1775-8. [PMID] 22735979.
2012
Enhancing Braden pressure ulcer risk assessment in acutely ill adult veterans.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 20(2):137-48 [DOI] 10.1111/j.1524-475X.2011.00761.x. [PMID] 22304370.
2012
Is there a relationship between throbbing pain and arterial pulsations?
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(22):7572-6 [DOI] 10.1523/JNEUROSCI.0193-12.2012. [PMID] 22649235.
2011
Effects of a father-based in-home intervention on perceived stress and family dynamics in parents of children with autism.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association. 65(6):679-87 [PMID] 22214112.
View on: PubMed
2011
In-Home Training for Fathers of Children with Autism: A Follow up Study and Evaluation of Four Individual Training Components.
Journal of child and family studies. 20(3):263-271 [PMID] 21654918.
View on: PubMed
2011
Mirror, mirror on the wall: what effectiveness research shows us about headache care.
Pain. 152(8):1695-1696 [DOI] 10.1016/j.pain.2011.03.009. [PMID] 21435787.
2011
Public health nursing case management for women receiving temporary assistance for needy families: a randomized controlled trial using community-based participatory research.
American journal of public health. 101(9):1759-68 [DOI] 10.2105/AJPH.2011.300210. [PMID] 21778474.
2010
Combining an Internal Pilot with an Interim Analysis for Single Degree of Freedom Tests.
Communications in statistics: theory and methods. 39(20):3717-3738 [PMID] 21037942.
View on: PubMed
2010
Comparison of depressive symptom severity scores in low-income women.
Nursing research. 59(6):380-8 [DOI] 10.1097/NNR.0b013e3181f84ee9. [PMID] 21048482.
2010
Injuries and unattended home exits in persons with dementia: a 12-month prospective study.
American journal of Alzheimer's disease and other dementias. 25(1):27-31 [DOI] 10.1177/1533317508323138. [PMID] 19001350.
2010
Sleep in dementia caregivers and the effect of a nighttime monitoring system.
Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing. 42(3):338-47 [DOI] 10.1111/j.1547-5069.2010.01337.x. [PMID] 20738745.
2009
The Beck Depression Inventory II factor structure among low-income women.
Nursing research. 58(6):400-9 [DOI] 10.1097/NNR.0b013e3181bee5aa. [PMID] 19918151.
2008
Adaptive clinical trials: progress and challenges.
Drugs in R&D. 9(4):229-42 [PMID] 18588354.
View on: PubMed
2008
GLUMIP 2.0: SAS/IML Software for Planning Internal Pilots.
Journal of statistical software. 28(7) [PMID] 27774042.
View on: PubMed
2007
Practical Methods for Bounding Type I Error Rate with an Internal Pilot Design.
Communications in statistics: theory and methods. 36(11) [DOI] 10.1080/03610920601143634. [PMID] 24363489.
2005
Longitudinal changes in bone density in children and adolescents with moderate to severe cerebral palsy.
The Journal of pediatrics. 146(6):769-75 [PMID] 15973316.
View on: PubMed
2004
Predicting low bone density in children and young adults with quadriplegic cerebral palsy.
Developmental medicine and child neurology. 46(6):416-9 [PMID] 15174534.
View on: PubMed

Grants

Dec 2020 ACTIVE
Genomic Profiling of T-cell Acute Lymphoblastic Leukemia in Children
Role: Principal Investigator
Funding: CHILDRENS HOSP PHILADELPHIA via NATL INST OF HLTH NCI
Oct 2020 – Jul 2021
Comprehensive Genomic Profiling to Identify Alterations Associated with Relapse for NCI Standard Risk B-lineage ALL and NCI High Risk B-lineage ALL with Favorable Genetic Features
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NCI
Apr 2019 ACTIVE
Children's Oncology Group Statistics and Data Center
Role: Principal Investigator
Funding: PUBLIC HLTH INST via NATL INST OF HLTH NCI
Mar 2019 ACTIVE
Wearable Technology Infrastructure to Enhance Capacity for Real-Time, Online Assessment and Mobility (ROAMM) of Intervening Health Events in Older Adults
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jul 2017 ACTIVE
Longitudinal, multimodal assessment of neuropsychological functioning in children with high-risk acute lymphoblastic leukemia: Do early changes predict later impairment
Role: Principal Investigator
Funding: CHILDRENS RESEARCH INSTITUTE via NATL INST OF HLTH NCI
Aug 2015 – Jan 2016
Dissemination of Amputee and Prosthetic Evidence-based Medicine (DAP-EM)
Role: Principal Investigator
Funding: TAMPA VA RESEARCH AND ED FOUNDATION INC
Jul 2015 – Jun 2020
Center for Precision Medicine in Leukemia
Role: Principal Investigator
Funding: ST JUDE CHILDRENS RESEARCH HOSPITAL via NATL INST OF HLTH NIGMS
Mar 2014 – Feb 2019
Children's Oncology Group Statistics and Data Center
Role: Project Manager
Funding: NATL INST OF HLTH NCI
Feb 2014 – Feb 2016
Sarcopenic transitions for predicting physical disability states
Role: Project Manager
Funding: SANOFI US SERVICES
Jan 2014 – Dec 2018
MtDNA variant modifiers of cardiopulmonary responsiveness to physical activity
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Dec 2011 – Nov 2015
Associations between Ambient Air Pollution and Adverse Outcomes in Florida
Role: Project Manager
Funding: NATL INST OF HLTH NIEHS
Aug 2011 – Jul 2016
Improving Dementia Caregiver Sleep and the Effect on Heart Disease Biomarkers
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Education

PhD
2007 · University of North Carolina at Chapel Hill
BA
2002 · University of North Carolina at Chapel Hill
BSPH
2002 · University of North Carolina at Chapel Hill

Teaching Profile

Courses Taught
2020-2021
PHC6790 Biostatistical Methods Using SAS
2013-2015,2017-2021,2020-2021
PHC7979 Advanced Research
2015,2019-2020
PHC7980 Research for Doctoral Dissertation
2014-2019
PHC6937 Special Topics in Public Health
2017
PHC6601 Seminar in Contemporary Public Health Issues
2017
PHC6946 Public Health Internship
2014
PHC6917 Supervised Research Project
2010-2011,2014
GMS6819 Design and Conduct Clinical Trials II
2010-2013
GMS6818 Design and Conduct Clinical Trials I
2013
GMS6862 Applied Biostatistics II
2009
GMS5905 Special Topics in Biomedical Sciences

Contact Details

Phones:
Business:
(352) 294-5918
Emails:
Business:
johnkair@ufl.edu