Zhiguang Huo

Zhiguang Huo,

Assistant Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5929
Business Email: zhuo@ufl.edu

About Zhiguang Huo

I am an assistant professor in Department of Biostatistics, University of Florida. In terms of statistical methodology development, I am interested in omics data integration, high-dimensional data, Bayesian methods, and optimization. In terms of genetic epidemiology, I am interested in Alzheimer’s disease, type 2 diabetes, and cardiovascular disease. In terms of collaborative research, I am interested in bioinformatics, genomic data applications.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-8032-4392

Publications

2021
A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis
The Journal of Pain. 22(11):1452-1466 [DOI] 10.1016/j.jpain.2021.04.018.
2021
BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program.
iScience. 24(4) [DOI] 10.1016/j.isci.2021.102307. [PMID] 33870128.
2021
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Science Advances. 7(43) [DOI] 10.1126/sciadv.abi9654. [PMID] 34669477.
2021
ESR1 ChIP-Seq Identifies Distinct Ligand-Free ESR1 Genomic Binding Sites in Human Hepatocytes and Liver Tissue.
International journal of molecular sciences. 22(3) [DOI] 10.3390/ijms22031461. [PMID] 33540646.
2021
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms
Molecular Metabolism. 43 [DOI] 10.1016/j.molmet.2020.101110. [PMID] 33137489.
2021
HCMMCNVs: Hierarchical Clustering Mixture Model of Copy Number Variants Detection using Whole Exome Sequencing Technology.
Bioinformatics (Oxford, England). [DOI] 10.1093/bioinformatics/btab183. [PMID] 33714997.
2021
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
The Journal of biological chemistry. 297(3) [DOI] 10.1016/j.jbc.2021.101023. [PMID] 34343564.
2021
Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications.
Briefings in bioinformatics. 22(6) [DOI] 10.1093/bib/bbab224. [PMID] 34117739.
2021
Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study
Diabetes Care. [DOI] 10.2337/dc21-0451.
2021
Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 79(3):1041-1054 [DOI] 10.3233/JAD-200176. [PMID] 33427733.
2021
Pharmacological Inhibition of CBP/p300 Blocks Estrogen Receptor Alpha (ERα) Function through Suppressing Enhancer H3K27 Acetylation in Luminal Breast Cancer
Cancers. 13(11) [DOI] 10.3390/cancers13112799. [PMID] 34199844.
2021
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2.
Molecular psychiatry. 26(8):4066-4084 [DOI] 10.1038/s41380-020-00958-2. [PMID] 33235333.
2020

Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults

Journal of Pain Research. Volume 13:2389-2400 [DOI] 10.2147/jpr.s260611.
2020

Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults

Journal of Pain Research. Volume 13:2389-2400 [DOI] 10.2147/jpr.s260611.
2020
Biomarkers that differentiate false positive urinalyses from true urinary tract infection.
Pediatric nephrology (Berlin, Germany). 35(2):321-329 [DOI] 10.1007/s00467-019-04403-7. [PMID] 31758242.
2020
Brain and blood metabolome for Alzheimer’s dementia: findings from a targeted metabolomics analysis
Neurobiology of Aging. 86:123-133 [DOI] 10.1016/j.neurobiolaging.2019.10.014. [PMID] 31785839.
2020
Corrigendum to brain and blood metabolome for Alzheimer’s dementia: findings from a targeted metabolomics analysis [Neurobiology of Aging Volume 86, February 2020, Pages 123-133].
Neurobiology of aging. 91 [DOI] 10.1016/j.neurobiolaging.2020.04.004. [PMID] 32312579.
2020
Design and Implementation of the Health Professions Simulation Assessment, a Tool to Assess Students’ Perceptions of Simulation Experiences
.
2020
Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial.
Acupuncture in medicine : journal of the British Medical Acupuncture Society. 38(1):53-60 [DOI] 10.1177/0964528419873670. [PMID] 31544469.
2020
Enrichment of genomic pathways based on differential DNA methylation profiles associated with chronic musculoskeletal pain in older adults: An exploratory study.
Molecular pain. 16 [DOI] 10.1177/1744806920966902. [PMID] 33073674.
2020
Kava as a Clinical Nutrient: Promises and Challenges.
Nutrients. 12(10) [DOI] 10.3390/nu12103044. [PMID] 33027883.
2020
Metabolic Profiling of Cognitive Aging in Midlife.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.555850. [PMID] 33250761.
2020
P-value evaluation, variability index and biomarker categorization for adaptively weighted Fisher’s meta-analysis method in omics applications.
Bioinformatics (Oxford, England). 36(2):524-532 [DOI] 10.1093/bioinformatics/btz589. [PMID] 31359040.
2020
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies.
Journal of hematology & oncology. 13(1) [DOI] 10.1186/s13045-020-00924-z. [PMID] 32718354.
2020
Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry.
Translational psychiatry. 10(1) [DOI] 10.1038/s41398-020-0742-9. [PMID] 32066699.
2020
Two-Way Horizontal and Vertical Omics Integration for Disease Subtype Discovery
Statistics in Biosciences. 12(1):1-22 [DOI] 10.1007/s12561-019-09242-6.
2020
What Can We Learn About Drug Safety and Other Effects in the Era of Electronic Health Records and Big Data That We Would Not Be Able to Learn From Classic Epidemiology?
The Journal of surgical research. 246:599-604 [DOI] 10.1016/j.jss.2019.09.053. [PMID] 31653413.
2019
BAYESIAN INDICATOR VARIABLE SELECTION TO INCORPORATE HIERARCHICAL OVERLAPPING GROUP STRUCTURE IN MULTI-OMICS APPLICATIONS
Annals of Applied Statistics. 13(4):2611-2636 [DOI] 10.1214/19-AOAS1271.
2019
Bayesian indicator variable selection to incorporate multi-layer overlapping group structure in multi-omics applications
Annals of Applied Statistics. 13(4):2611-2636
2019
BAYESIAN LATENT HIERARCHICAL MODEL FOR TRANSCRIPTOMIC META-ANALYSIS TO DETECT BIOMARKERS WITH CLUSTERED META-PATTERNS OF DIFFERENTIAL EXPRESSION SIGNALS.
The annals of applied statistics. 13(1):340-366 [DOI] 10.1214/18-AOAS1188. [PMID] 31007807.
2019
Bcl11b prevents fatal autoimmunity by promoting T reg cell program and constraining innate lineages in T reg cells
Science Advances. 5(8) [DOI] 10.1126/sciadv.aaw0480. [PMID] 31457080.
2019
Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia.
Nature communications. 10(1) [DOI] 10.1038/s41467-019-11335-1. [PMID] 31399567.
2019
DNA methylation variability in Alzheimer’s disease
Neurobiology of Aging. 76:35-44 [DOI] 10.1016/j.neurobiolaging.2018.12.003. [PMID] 30660039.
2019
Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults.
Molecular pain. 15 [DOI] 10.1177/1744806919871819. [PMID] 31394966.
2019
Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis.
The Journal of pediatrics. 209:146-153.e1 [DOI] 10.1016/j.jpeds.2019.01.012. [PMID] 30905425.
2019
MetaOmics: analysis pipeline and browser-based software suite for transcriptomic meta-analysis.
Bioinformatics (Oxford, England). 35(9):1597-1599 [DOI] 10.1093/bioinformatics/bty825. [PMID] 30304367.
2019
Parent Training for Feeding Problems in Children With Autism Spectrum Disorder: Initial Randomized Trial.
Journal of pediatric psychology. 44(2):164-175 [DOI] 10.1093/jpepsy/jsy063. [PMID] 30101320.
2019
The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.
Proteomics. 19(13) [DOI] 10.1002/pmic.201800394. [PMID] 31070281.
2019
Two-way Horizontal and Vertical Omics Integration for Disease Subtype Discovery
. 1-22
2018
Image-derived generative modeling of pseudo-macromolecular structures-towards the statistical assessment of Electron CryoTomography template matching
.
2018
Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach
Scientific Reports. 8(1) [DOI] 10.1038/s41598-018-27903-2. [PMID] 29942049.
2018
Meta-analytic Principal Component Analysis in Integrative Omics Application
Bioinformatics. 34(8):1321-1328 [DOI] 10.1093/bioinformatics/btx765. [PMID] 29186328.
2018
Opposite Molecular Signatures of Depression in Men and Women
Biological Psychiatry. 84(1):18-27 [DOI] 10.1016/j.biopsych.2018.01.017. [PMID] 29548746.
2018
Transcriptome Alterations of Prefrontal Cortical Parvalbumin Neurons in Schizophrenia
Molecular Psychiatry. 23(7):1606-1613 [DOI] 10.1038/mp.2017.216. [PMID] 29112193.
2017
Integrative Sparse K-Means With Overlapping Group Lasso in Genomic Applications for Disease Subtype Discovery.
The annals of applied statistics. 11(2):1011-1039 [DOI] 10.1214/17-AOAS1033. [PMID] 28959370.
2017
MetaDCN: meta-analysis framework for differential co-expression network detection with an application in breast cancer.
Bioinformatics (Oxford, England). 33(8):1121-1129 [DOI] 10.1093/bioinformatics/btw788. [PMID] 28031185.
2017
Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders.
Biological psychiatry. 82(8):594-600 [DOI] 10.1016/j.biopsych.2017.03.018. [PMID] 28476208.
2016
Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data.
Nucleic acids research. 44(5) [DOI] 10.1093/nar/gkv1234. [PMID] 26582927.
2016
Meta-analytic framework for sparse K-means to identify disease subtypes in multiple transcriptomic studies.
Journal of the American Statistical Association. 111(513):27-42 [PMID] 27330233.
View on: PubMed
2015
Genomic Copy Number Variations in the Genomes of Leukocytes Predict Prostate Cancer Clinical Outcomes.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0135982. [PMID] 26295840.
2015
Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition.
Cancer prevention research (Philadelphia, Pa.). 8(10):1000-9 [DOI] 10.1158/1940-6207.CAPR-15-0178. [PMID] 26290394.
2012
An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection.
Bioinformatics (Oxford, England). 28(19):2534-6 [PMID] 22863766.
View on: PubMed

Grants

Jun 2021 ACTIVE
Reducing tobacco-associated lung cancer risk: A randomized clinical trial of AB-free kava
Role: Co-Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2021 ACTIVE
Novel Mechanism of Action and Translational Potential of the HDAC Inhibitor SR-4370 for Treating Breast Cancer
Role: Co-Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Mar 2021 ACTIVE
Circadian Clock and Muscle Health
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Dec 2020 ACTIVE
Contributions of Tobacco use, NNK, and Stress to Lung Cancer Risk Disparities between AA and CA Male Smokers
Role: Co-Investigator
Funding: LUNG CANCER RESEARCH FOUNDATION
Oct 2020 ACTIVE
Novel biomarkers for alpha 1-antitrypsin mediated liver disease in circulating exosomes
Role: Other
Funding: ALPHA ONE FOU
Sep 2020 ACTIVE
Circadian clock regulation of myocardial ion channel expression and function
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2020 ACTIVE
Immune injury as a driver for the development of ascending aortic aneurysms and dissections
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jun 2020 ACTIVE
Molecular mechanisms and pharmacologic targeting of lipogenesis in breast cancer
Role: Other
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2020 ACTIVE
Biobehavioral basis of knee osteoarthritis pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2019 ACTIVE
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation.
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jul 2019 – Aug 2020
Role of Bcl11b in CD4+ T cells and innate lymphoid cells
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Aug 2018 ACTIVE
Mechanisms of Oxytocins Analgesia in Older Adults
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jun 2018 ACTIVE
Study of muscle, mobility, and aging (SOMMA)
Role: Co-Investigator
Funding: CALIFORNIA PACIFIC MEDICAL CTR via NATL INST OF HLTH NIA
Apr 2018 ACTIVE
Neural mechanisms underlying psychosocial contributions to ethnic group differences in pain
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Sep 2017 – Aug 2020
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular Carcinoma
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Dec 2016 ACTIVE
UF PASS: Regulation of exercise transducers
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jun 2016 – Aug 2021
Genome-wide Profiling of Brain DNA Hydroxymethylome in Alzheimers Disease
Role: Project Manager
Funding: NATL INST OF HLTH NIA

Education

Ph.D
2017 · University of Pittsburgh
M.S.
2012 · University of Pittsburgh
B.S.
2011 · Harbin Institute of Technology

Teaching Profile

Courses Taught
2017-2021
PHC6068 Biostatistical Computing
2019-2021
PHC7979 Advanced Research
2018-2019,2021
PHC6905 Independent Study
2018
STA7980 Research for Doctoral Dissertation
2017
PHC6937 Special Topics in Public Health

Contact Details

Phones:
Business:
(352) 294-5929
Emails:
Business:
zhuo@ufl.edu