About Arlene H Naranjo
Dr. Arlene Naranjo is a Research Associate Professor in the Department of Biostatistics and Associate Program Director of the Children’s Oncology Group (COG) Statistics & Data Center (SDC) at the University of Florida. As lead statistician for neuroblastoma with the COG SDC, Dr. Naranjo is responsible for designing future studies, performing sample size and power calculations, monitoring open studies, and analyzing results from pediatric clinical trials. Her research interests include clinical trials design & analysis, survival analysis, longitudinal data analysis, and hierarchical linear models. Dr. Naranjo helped develop and currently co-teaches the graduate-level course Design and Conduct of Clinical Trials.
My area of specialization is in the design, conduct, analysis, and reporting of results of pediatric cancer clinical trials for patients with neuroblastoma. I have worked for over a decade in this area and my expertise is in clinical trial designs for small patient populations, statistical applications to clinical trials, survival analysis, group sequential methods for assessing early evidence of efficacy and futility, prognostic factor analysis, and biomarker optimal cut-point determination. As a member of the Children’s Oncology Group (COG) Statistics & Data Center (SDC), I have designed and analyzed data from clinical trials ranging from small Phase II and pilot studies with short-term endpoints such as response to large Phase III trials with event-free and overall survival long-term endpoints. In collaboration with COG investigators from all over the world, I have led the statistical effort to identify new molecular targets for development of novel therapies, refine disease response assessment, better understand the genetic basis of neuroblastoma, and share the datasets with academic researchers worldwide to improve our understanding of the pathogenesis of this neoplasm and improve patient outcomes. This work has been funded by the multi-million COG SDC grant and related correlative study grants using annotated banked tumor samples from patients enrolled in COG trials.
- Clinical Trials Design & Analysis
- Longitudinal Data Analysis
- Survival Analysis