Rhonda L Bacher

Rhonda L Bacher

Assistant Professor

Department: PHHP-COM BIOSTATISTICS
Business Phone: (352) 294-5914
Business Email: rbacher@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-5787-476X

Areas of Interest
  • Biostatistics
  • Genomics
  • Statistical Genetics

Publications

2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes. [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes. [DOI] 10.2337/db20-0937. [PMID] 33419759.
2020
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.00611. [PMID] 32351504.
2020
Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.01289. [PMID] 32670283.
2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.
Diabetes. 69(3):413-423 [DOI] 10.2337/db19-0942. [PMID] 31826866.
2020
Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis
PLoS One. 15(9) [DOI] 10.1371/journal.pone.0239711.
2020
Single Cell RNA-SEQ of Human Myeloid Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets with Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.). [DOI] 10.1097/SHK.0000000000001671. [PMID] 33021571.
2019
Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics
Plos Computational Biology. 15(12) [DOI] 10.1371/journal.pcbi.1007543.
2019
Normalization for Single-Cell RNA-Seq Data Analysis.
Methods in molecular biology (Clifton, N.J.). 1935:11-23 [DOI] 10.1007/978-1-4939-9057-3_2. [PMID] 30758817.
2018
Trendy: segmented regression analysis of expression dynamics in high-throughput ordered profiling experiments.
BMC bioinformatics. 19(1) [DOI] 10.1186/s12859-018-2405-x. [PMID] 30326833.
2018
Spatial patterns of gene expression are unveiled in the chick primitive streak by ordering single-cell transcriptomes.
Developmental biology. 439(1):30-41 [DOI] 10.1016/j.ydbio.2018.04.007. [PMID] 29678445.
2017
An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer’s Disease
Frontiers in Aging Neuroscience. 9
2017
SCnorm: robust normalization of single-cell RNA-seq data
. 14(6):584-586
2017
Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress
PLoS Biology. 15(12)
2017
Species-Specific Developmental Timing is Maintained by Pluripotent Stem Cells Ex Utero
. 423(2):101-110
2017
Statistical Methods for Latent Class Quantitative Trait Loci Mapping
Genetics. 208(2)
2016
Design and computational analysis for single-cell RNA-sequencing experiments
Genome Biology. 17

Grants

Jan 2021 ACTIVE
Developing a Novel PROTAC-Based NR4A1 Degrader for Breast Cancer Therapy
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2019 ACTIVE
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2019 – Aug 2020
Single cell sequencing for islet-reactive T cell clonotype and transcript signatures
Role: Co-Investigator
Funding: JDRF
Apr 2019 – Mar 2020
A Composite Serological Risk Score to Predict Type 1 Diabetes Progression and Clinical Diagnosis
Role: Co-Investigator
Funding: JDRF
Aug 2018 – Aug 2019
Uncovering the Life Clock of Red Blood Cells Using Single-Cell Analysis
Role: Principal Investigator
Funding: JAYNE KOSKINAS TED GIOVANIS FOU
Jun 2018 ACTIVE
Characterization of SLE-susceptibility loci on mouse chromosome 1
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jun 2018 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Project Manager
Funding: NATL INST OF HLTH NIAID

Teaching Profile

Courses Taught
2020-2021
PHC7979 Advanced Research
2019-2020
PHC6601 Seminar in Contemporary Public Health Issues
2020
PHC6088 Statistical Analysis of Genetic Data
2020
HSC4913 Supervised Resrch Exp
2019-2020
PHC6946 Public Health Internship
2018-2019
PHC6937 Special Topics in Public Health

Contact Details

Phones:
Business:
(352) 294-5914
Emails:
Business:
rbacher@ufl.edu