The Department of Biostatistics offers courses for three degree programs within the department (PhD, MS, and MPH) as well as courses for students from other departments and program.  Students in the Department of Biostatistics also take courses offered by the Department of Statistics and the College of Public Health and Health Professions.

Schedule of Department of Biostatistics Course Offerings – Spring 2018

Spring 2018 Course Graph

MS and PhD Courses

Most courses in the MS and PhD program require three semesters of calculus and one semester of linear algebra.

GMS 6827 – Advanced Clinical Trials (3)
This course covers the statistical principles and methods used in the design and analysis of clinical trials. Topics include group sequential designs, adaptive clinical trials, and Statistical Monitoring of Clinical Trials.  Syllabus

PHC 6020 – Clinical Trials Methods (3)
This course will introduce some basic statistical concepts and methods used in Epidemiology and will focus on the statistical principles and methods used in clinical trials, including phase I to IV clinical trials. Although the class will have emphasis on phase III trials, we will also discuss the feature and statistical issues in phase I and II clinical trials. For phase III trials, we will discuss ways of treatment allocation that will ensure valid inference on treatment comparison. Other topics include sample size calculation, survival analysis and early stopping of a clinical trial and noncompliance.  Syllabus This course is offered to our campus and online students.

PHC 6050c – Biostatistical Methods I (3)
This course covers linear models methodology including simple and multiple regression and analysis of variance including factorial and block designs. This course covers regression for categorical data, random effects models for correlated data, and nonparametric and semiparametric regression. Syllabus This course is offered to our campus and online students.

PHC 6051 – Biostatistical Methods II (3)
Biostatistical data analysis using generalized linear models, generalized linear mixed models, semiparametric and nonparametric regression, and neural networks; theory and practice in the health sciences. Syllabus This course is offered to our campus and online students.

PHC 6063 – Biostatistical Consulting (3)
This course covers communication, management, organization, computational and biostatistical thinking skills necessary to consulting in biostatistics. Syllabus

PHC 6068 — Biostatistical Computing (3)
Algorithms for statistical computing and their applications in biostatistics. Computational techniques for data analysis, random number generation, Monte Carlo integration, stochastic optimization. High-dimensional data analysis, large scale hypothesis testing, stochastic optimization, Markov chain Monte Carlo (MCMC), missing data analysis, selected biological applications. Syllabus

PHC 6092 — Introduction to Biostatistical Theory (3)
Concepts and principles of statistical theory, including probability and random variables, parameter estimation, confidence intervals, hypothesis testing, asymptotic analysis, Bayesian inference, statistical decision theory and linear models. Syllabus This course is offered to our campus and online students.

PHC 6937 – Applied Biostatistical Computing Using SAS
The purpose of this course is to introduce and prepare students for biostatistical computing using the SAS statistical software. It builds on the knowledge obtained in the Biostatistical Methods I and II courses by reinforcing the material and focusing on application within the SAS framework. This will prepare students for future SAS programming and analysis needs within future coursework, graduate assistantships, as well as for future marketability and employment. Topics covered include data management, frequency tables, linear and non-linear models, longitudinal data analysis, Matrix programming, simulation, and using SAS macros.  Syllabus

PHC 6937 – Applied Survival Analysis (3)
This course covers survival analysis, Kaplan-Meier estimates, proportional hazards model, related tests, phase I, II, and III clinical trials, designs, and protocols. Syllabus
This course is designed for non-math majors wishing to take STA 6177: Applied Survival Analysis.

PHC 6937 – Biostatistical Literacy (3)
This course will involve minimal calculation and offers no formal training in statistical software. The focus will be on understanding statistical concepts, when to use a given method, and how to interpret the results. Computations and computer programming used to analyze raw data will not be emphasized. Syllabus

 PHC 6937 – Genetic Data Analysis (3)
An introduction to statistical procedures in human and animal genetics, including Hardy-Weinberg equilibrium, basic linkage analysis, linkage disequilibrium, and association with disease. The goal is to prepare students for potential research in statistical genetics and genomics. Syllabus

PHC 6937 – Stochastic Modeling (3)
The student will learn both the theory and practice of stochastic processes and modeling.  This will include the theory of random phenomena that is concerned with the flow of events in time and space, especially those exhibiting highly variable behavior that can be described by probability distributions.  Specifically, the student will learn to deal with the branching process, random walks, martingales, Markov processes, Poisson process, counting processes, birth and death processes as applied to the health sciences biology.  Many of the examples and illustrations of the methods will be in the area infectious diseases.  There will be an emphasis on learning methods of strong scientific importance as opposed to purely mathematical theory.  Syllabus

PHC 6937 – Stochastic Epidemic Modeling (1)
The student will learn theory and applications of modelling epidemic outbreaks and statistical inference for such. The focus will however be on methodology. The theory involves deterministic models, usually presented with sets of differential equations, and stochastic models. Large population properties will be derived using probabilistic methods such as central limit theory, branching process theory, theory for population processes, l random graph theory and coupling. Statistical methods will also be presented using e.g. martingales, counting processes and the likelihood theory.  Syllabus

PHC 6937 – Analytic Methods for Infectious Diseases (3)
This course will introduce concepts of infectious disease epidemiology and study designs and analytic methods for evaluating interventions. Especially the relation between the underlying transmission dynamics and the design and evaluation of interventions will be discussed. Special emphasis will be on the design and evaluation of vaccination and vaccination programs. We will present methods for real-time statistical evaluation of interventions of emerging infectious diseases. Statistical and mathematical methods include survival analysis, likelihood methods, stochastic processes, network theory, and stochastic and deterministic transmission models. Examples include case studies in influenza, Ebola, dengue, Zika, cholera, and others. Presentations are largely statistical and mathematical, but with a focus on concepts. Syllabus

PHC 6937 – Frontiers in Biostatistics  (3)
This course will introduce biostatistics Masters and PhD students to current issues and methods in modern biostatistics research. Current faculty will present selected topics from their current research. Syllabus

PHC 6937 – Survey of Biostat Methods (3)
This course is a survey of biostatistical methods beyond one and two sample techniques covered in PHC 6052. Advanced topics will be selected from areas such as regression models for clustered/correlated data, missing data methods, causal inference, model/variable selection, multiple testing, multivariate methods, or non-parametric methods. Focus will be on the application of these techniques to data from the health sciences. SAS will be the main software package for this course. Syllabus

PHC 7056 – Longitudinal Data Analysis (3)
Likelihood-based and semiparametric methods for longitudinal data and methods to deal with missing data in both settings. Discussion of impact of missing data both theoretically and practically on inference, and approaches to conduct sensitivity analysis for inference. Syllabus

PHC 7066 – Large Sample Theory (3)
Detailed introduction to large sample theory and its application in univariate and multivariate parametric and nonparametric estimation. Syllabus

PHC 7090 – Advanced Biostatistical Methods I (3)
Theory and application for estimation and hypothesis testing for independent data using linear models. Principles of Frequentist and Bayesian estimation and inference. Application using statistical software. Writing data analysis reports. Syllabus

PHC 7091 — Advanced Biostatistical Methods II (3)
Theory and application for independent and dependent data using generalized linear models and generalized linear mixed models. Bayesian and Frequentist inference. Application using statistical software. Writing data analysis reports. Syllabus

PHC 7925 – Biostat Journal Club (1)
This class will meet weekly to present, review and discuss current articles in biostatistics or statistics journals or discipline-specific (e.g. medicine, public health, epidemiology) articles with substantive biostatistical content. Syllabus

PHC 7979 – Advanced Research (Variable)

PHC 7980 – Research for Doctoral Dissertation (Variable)

STA 6177 – Applied Survival Analysis (3)
This course covers survival analysis, Kaplan-Meier estimates, proportional hazards model, related tests, phase I, II, and III clinical trials, designs, and protocols. Syllabus

STA 7179 – Advanced Survival Analysis (3)
Theoretical introduction to statistical inferential procedures useful for analyzing randomly right censored failure time data.

MPH Courses

The following courses are offered as part of the MPH program at the University of Florida.  These courses may also be appropriate for non-majors in a variety of fields who wish to learn more about the application of statistical methods in the health sciences.

PHC 6050 – Statistical Methods Health Science 1 (3)
This course covers statistical vocabulary, methods for descriptive data analysis, the fundamentals of probability and sampling distributions, methods for statistical inference and hypothesis testing based on one or two samples, categorical data analysis and linear regression. Data analysis will be conducted in SPSS. Syllabus

PHC 6052–Introduction to Biostatistical Methods (3)
Introduction to the concepts and methods of biostatistical data analysis. Topics include descriptive statistics, probability, standard probability distributions, sampling distributions, point and confidence interval estimation, hypothesis testing, power and sample size estimation, one- and two-sample parametric and non-parametric methods for analyzing continuous or discrete data, and simple linear regression. SAS statistical software for data management, statistical analysis and power calculations.

PHC 6053 – Regression Methods for Health and Life Sciences (3)
This course introduces graduate students in fields other than statistics to a wide range of modern regression methods. Emphasis is on modeling driven by actual data from studies in a variety of areas, primarily from health, biology, and ecology. The primary topics are multiple linear regression, logistic regression, and Poisson regression. A main goal is to learn what approach to use among the linear and nonlinear models, and how to determine whether the fit is adequate. By the end of the course, students will achieve competency in carrying out the analyses in SAS. Syllabus

PHC 6937 – Applied Survival Analysis (3)
This course discusses “time to event” data, where the event can be response to treatment, relapse of disease, or death. Often we wish to quantify the relationship between the time to event and prognostic factors such as mode of therapy, age of patient, and severity of disease. This course will cover inference for a single population, methods for comparison of two or more populations, and methods for conducting regression analysis. Procedures will include the Kaplan-Meier estimator, the log-rank test, and Cox proportional hazards regression.   Syllabus


Other Department of Biostatistics Courses

The following courses are designed to give clinicians in the UF Health Science Center an opportunity to learn more about the application of statistical methods.  These courses may also be appropriate for non-majors in a variety of fields who wish to learn more about the application of statistical methods in the health sciences.

PHC 6937 – Design and Conduct of Clinical Trials (3)
This course focuses on various study designs, including phase I-IV, single-arm, crossover, factorial, and sequential multi-stage, plus the means to allocate study participants to appropriate treatment groups using randomization (blocked or stratified) and prognostic factors. In addition, the protection of study participants and the need for equipoise is covered, including regulatory restrictions and the latest patient privacy regulations for the dissemination and use of data associated with the participants in clinical trials. The importance of informed consent and the use of intent-to-treat analysis will also be emphasized. Syllabus

GMS 6841 – Design and Analysis of Translational Research in Biomedical Sciences (2)
Common statistical analysis methods and widely used experimental design techniques including hypothesis testing, study design, confidence intervals, multiple regression, longitudinal data analysis, Non-linear regression for pharmacokinetics and pharmacodynamics, Kaplan-Meier estimates, proportional hazards models, randomization, and power analysis.  Syllabus

GMS 6861 – Applied Biostatistics I (3)
Basic probability and distribution concepts and statistical analysis methods, including descriptive measures, point estimation, hypothesis testing (e.g., t test, analysis of variance, chi-square test etc.), confidence interval, simple linear regression and some nonparametric methods. SPSS will be used for basic statistical analyses. Syllabus

GMS 6862 – Applied Biostatistics II (3)
Provides background to apply and appropriately interpret statistical applications in the medical and health related fields, and to formulate clinical and basic science research questions in statistical terms. Syllabus

Department of Statistics Courses

The following courses offered by the Department of Statistics are taken by MS or PhD students in the Department of Biostatistics.

STA 6326 – Introduction to Theoretical Statistics I (3)
This course covers theory of probability including probability spaces, continuous and discrete distributions, functions of random variables, multivariate distributions, expectation, conditional expectation, central limit theorem, useful convergence results, sampling distributions, distributions of order statistics, and empirical distribution function.

STA 6327 – Introduction to Theoretical Statistics II (3)
This course covers estimation and hypothesis testing. Sufficiency, information, estimation, maximum likelihood, confidence intervals, uniformly most powerful tests, likelihood ratio tests, sequential testing, univariate normal inference, decision theory, analysis of categorical data.

STA 7346 – Statistical Inference (3)
Decision rules and risk functions. Sufficiency, Minimax, and Bayes rules for estimating location and scale parameters.

Public Health Courses

The following courses offered by the MPH program in the College of Public Health and Health Professions are taken by MPH, MS, and PhD students in the Department of Biostatistics.

PHC 6001—Principles of Epidemiology in Public Health (3)
Overview of epidemiology methods used in research studies that address disease patterns in community and clinic-based populations. Includes distribution and determinants of health-related states or events in specific populations and application to control of health problems.

HSA 6114—Introduction to the U.S. Health Care System (3) – This course is designed to familiarize students with basic concepts and ideas concerning the distribution of health and illness, the organization of the health care system and the relationship of one to the other. Definitions of health and illness, as well as the historical context for developments of our health care system are discussed and debated. The course concludes with a discusssion on trends that could impact the health care system in the future. Students should come to class ready to discuss and debate the major themes related to health and distribution of disease, the ability of the U.S. health care system to meet the needs of the population, as well as the policy environment that influences access to health care services.

PHC 6313—Environmental Health Concepts in Public Health (3 or 2)
Survey of major topics of environmental health. Sources, routes, media, and health outcomes associated with biological, chemical, and physical agents in environment. Effects of agents on disease, water quality, air quality, food safety, and land resources. Current legal framework, policies, and practices associated with environmental health and intended to improve public health.

PHC 6410/formerly 6406—Psychological, Behavioral, and Social Issues in Public Health (3) 
Health behavior from an ecological perspective; includes primary, secondary and tertiary prevention across a variety of settings; incorporates behavioral science theory and methods.

PHC6937 – Introduction to Public Health (3)

The purpose of this course is to provide a broad introduction to public health as well as an understanding about how their PhD specializations contribute to achieving the goals of public health.  A full syllabus for this course can be found in the archives here:

PHC6937 – Public Health Computing (3) – Formerly PHC6055, PHC6080, PHC6081
This is a three credit course which covers using SAS and R to process and analyze public health data. Students will learn how to input, store, modify, display and perform common analyses of public health data using SAS and R. Although we will discuss results, this course does NOT teach statistical methods. Syllabus